Manchon M, Kopp N, Rouzioux J M, Miachon S
C R Acad Sci III. 1986;302(4):131-4.
The characteristics of benzodiazepine binding sites (distribution, number, affinity) were defined on frozen sections of suicide's hippocampus (death by hanging) labeled with 3H flunitrazepam and compared to data previously obtained on control brains. The study was carried out qualitatively by autoradiography (distribution) and quantitatively by a biochemical technique (number and affinity). As a whole, the characteristics of BZD binding sites were not modified in relation to controls, except for a very slight decrease in affinity of subtype I.
使用3H氟硝西泮标记自杀者(缢死)海马体的冰冻切片,确定苯二氮䓬结合位点的特征(分布、数量、亲和力),并与先前在对照大脑中获得的数据进行比较。该研究通过放射自显影法进行定性(分布),并通过生化技术进行定量(数量和亲和力)。总体而言,除了I型亚型的亲和力略有下降外,苯二氮䓬结合位点的特征与对照组相比没有改变。