暴力自杀受害者海马体中的苯二氮䓬结合位点及其调节剂

Benzodiazepine binding sites and their modulators in hippocampus of violent suicide victims.

作者信息

Rochet T, Kopp N, Vedrinne J, Deluermoz S, Debilly G, Miachon S

机构信息

INSERM U171-CNRS URA 1195, Laboratorie de Neurochimie Fonctionnelle, Hôpital Sainte-Eugénie, Pierre-Benite, France.

出版信息

Biol Psychiatry. 1992 Nov 15;32(10):922-31. doi: 10.1016/0006-3223(92)90181-x.

DOI:10.1016/0006-3223(92)90181-x

PMID:1334714

Abstract

Benzodiazepine binding sites were studied by autoradiography in several hippocampic layers in brains of drug-free violent suicide victims (hanging) and matched controls. Kd was increased in suicides, and when brain sections from control subjects were incubated in the bath fluid that had previously served to incubate sections from suicides, Kd was increased in the same way. Results are discussed in terms of possible modulators of benzodiazepine binding sites, mainly tissue GABA and amino acid concentrations.

摘要

通过放射自显影术，在无药物使用史的暴力自杀受害者（缢死）及相匹配的对照者大脑的多个海马层中研究了苯二氮䓬结合位点。自杀者的解离常数（Kd）升高，并且当将对照受试者的脑切片置于先前用于孵育自杀者脑切片的浴液中时，Kd也以相同方式升高。从苯二氮䓬结合位点可能的调节因子，主要是组织γ-氨基丁酸（GABA）和氨基酸浓度方面对结果进行了讨论。