Department of Radiology, University of Occupational and Environmental Health, Kitakyushu, Japan.
Department of Psychiatry, University of Occupational and Environmental Health, Kitakyushu, Japan.
Transl Psychiatry. 2018 Aug 1;8(1):141. doi: 10.1038/s41398-018-0174-y.
Recently, accumulated evidence has indicated a role of inflammation in the pathogenesis of major depressive disorder (MDD). Therefore, we evaluated the relationship between white matter integrity and serum cytokine levels during the first depressive episode in drug-naive MDD patients, using a tract-based spatial statistics (TBSS) method. A total of 35 drug-naive MDD patients with a first depressive episode and 35 healthy subjects (HS) underwent diffusion tensor imaging, and an analysis was conducted using TBSS. We measured serum cytokine levels (interleukin [IL]-1β, IL-6, interferon-γ, and tumor necrosis factor-α). Fractional anisotropy (FA) values of the bilateral inferior fronto-occipital fasciculus (IFOF) and genu of the corpus callosum in MDD patients were decreased significantly to the HS (p < 0.05 with family-wise error [FWE] correction) and were significantly inversely correlated with the IL-1β levels (p < 0.05, with FWE correction). No regions showed a correlation between FA values and other serum cytokine levels. Our results suggested that the microstructural changes in IFOF and genu of the corpus callosum are associated with the high IL-1β levels in the early stage of MDD.
最近，越来越多的证据表明炎症在重度抑郁症（MDD）的发病机制中起作用。因此，我们采用基于束的空间统计学（TBSS）方法，评估了首次发作的未经药物治疗的 MDD 患者的白质完整性与血清细胞因子水平之间的关系。共纳入 35 例首次发作的未经药物治疗的 MDD 患者和 35 例健康对照者（HS）进行弥散张量成像，并采用 TBSS 进行分析。我们测量了血清细胞因子水平（白细胞介素[IL]-1β、IL-6、干扰素-γ和肿瘤坏死因子-α）。MDD 患者双侧下额枕束（IFOF）和胼胝体膝部的各向异性分数（FA）值明显低于 HS（校正后的家族性错误率[FWE]为 p<0.05），且与 IL-1β水平呈显著负相关（校正后的 FWE 为 p<0.05）。FA 值与其他血清细胞因子水平之间没有相关性。我们的结果表明，IFOF 和胼胝体膝部的微观结构变化与 MDD 早期高 IL-1β水平有关。
