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成年创伤性脑损伤患者颅底骨折的分析及临床意义

Analysis and Clinical Importance of Skull Base Fractures in Adult Patients with Traumatic Brain Injury.

作者信息

Sivanandapanicker Jyothish, Nagar Milesh, Kutty Raja, Sunilkumar B S, Peethambaran Anilkumar, Rajmohan B P, Asher Prasanth, Shinihas V P, Mohandas K, Jain Sourabh, Sharma Saurabh

机构信息

Department of Neurosurgery, Government Medical College, Thiruvananthapuram, Kerala, India.

Department of General Surgery, Government Medical College, Thiruvananthapuram, Kerala, India.

出版信息

J Neurosci Rural Pract. 2018 Jul-Sep;9(3):370-375. doi: 10.4103/jnrp.jnrp_38_18.

Abstract

AIMS AND OBJECTIVES

Basal skull fracture (BSF) is rare in head injury (HI) patients and occasionally goes unnoticed which may lead to cerebrospinal fluid (CSF) fistula. With changing trends in HI, there is a need to reassess incidence and pattern of BSF pattern, CSF leak, meningitis, and management protocol, especially in this part of the world where detailed literature is lacking.

SUBJECTS AND METHODS

We closely followed adult patients admitted with BSF in our institute between January 2013 and December 2014. Associated clinical features were recorded. In case of CSF leak, detailed CSF study was done and patients were managed accordingly. Patients with persistent CSF leak were managed surgically.

RESULTS

During the study period, 194 of 5041 HI patients had evidence of BSF (3.85%). BSF was most commonly associated with moderate-to-severe HI (73.19%). About 81.44% patients were male and 29.9% were <30 years. Most common cause was road traffic accident (84.54%). Isolated anterior cranial fossa (ACF) fracture was most common (50%). About 63.92% patients had raccoon eyes. Forty-three patients had CSF leak with CSF rhinorrhea being more common. Culture of only 5 patients suggested bacterial meningitis. CSF leak lasted for more than 10 days in 8 patients, of which 4 patients required surgical repair.

CONCLUSIONS

BSF is rare in victims of HI. It is more common in young adult males. ACF fractures are most common in our setup. Clinical signs of BSF are supportive but not definitive; high resolution computed tomography head is gold standard to detect BSF. CSF leak is rare and most of the cases can be managed conservatively. Leak persisting more than 7-10 days has high risk of developing meningitis and likely to need surgical intervention.

摘要

目的与目标

颅底骨折(BSF)在颅脑损伤(HI)患者中较为罕见,有时会被忽视,这可能导致脑脊液(CSF)漏。随着HI趋势的变化,有必要重新评估BSF的发生率、类型、CSF漏、脑膜炎及治疗方案,尤其是在世界上这一缺乏详细文献的地区。

研究对象与方法

我们密切随访了2013年1月至2014年12月间我院收治的成年BSF患者。记录相关临床特征。对于CSF漏患者,进行详细的CSF检查并相应地进行治疗。持续性CSF漏患者接受手术治疗。

结果

在研究期间,5041例HI患者中有194例有BSF证据(3.85%)。BSF最常与中重度HI相关(73.19%)。约81.44%的患者为男性,29.9%的患者年龄小于30岁。最常见的病因是道路交通事故(84.54%)。孤立的前颅窝(ACF)骨折最常见(50%)。约63.92%的患者有熊猫眼。43例患者有CSF漏,其中CSF鼻漏更为常见。仅5例患者的培养结果提示细菌性脑膜炎。8例患者的CSF漏持续超过10天,其中4例患者需要手术修复。

结论

BSF在HI受害者中罕见。在年轻成年男性中更常见。在我们的研究中,ACF骨折最常见。BSF的临床体征有辅助诊断价值但不具有确定性;头部高分辨率计算机断层扫描是检测BSF的金标准。CSF漏罕见,大多数病例可保守治疗。漏持续超过7 - 10天有发生脑膜炎的高风险,可能需要手术干预。

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