Gargani G, Pacetti A M
Chemioterapia. 1986 Feb;5(1):7-13.
The Authors tested piperacillin, azlocillin, aztreonam, cefotaxime, ceftizoxime, ceftriaxone, cefotetan, moxalactam, gentamicin, sisomicin and dibekacin, on about 120 strains of the genus Brucella, using as control drugs tetracycline, streptomycin and rifampicin. Cefotaxime, ceftizoxime, gentamicin, and sisomicin exhibited antibrucella activity comparable to that of tetracycline and just a little superior to that of rifampicin. Among the aminoglycosides tested, gentamicin, sisomicin and dibekacin were, in decreasing order, more active than streptomycin. For all the other drugs tested there was a large variability among the brucella strains, with roughly a peak of activity on the strains which have a history of repeated in vitro passages.
作者使用四环素、链霉素和利福平作为对照药物，对大约120株布鲁氏菌属菌株进行了哌拉西林、阿洛西林、氨曲南、头孢噻肟、头孢唑肟、头孢曲松、头孢替坦、莫拉维酸、庆大霉素、西索米星和地贝卡星的测试。头孢噻肟、头孢唑肟、庆大霉素和西索米星表现出的抗布鲁氏菌活性与四环素相当，略优于利福平。在所测试的氨基糖苷类药物中，庆大霉素、西索米星和地贝卡星的活性依次比链霉素更强。对于所有其他测试药物，布鲁氏菌菌株之间存在很大差异，在有多次体外传代历史的菌株上活性大致有一个峰值。
