一项荟萃分析显示，加巴喷丁治疗带状疱疹后神经痛的疗效和安全性来自随机对照试验。
A Meta-Analysis of Therapeutic Efficacy and Safety of Gabapentin in the Treatment of Postherpetic Neuralgia from Randomized Controlled Trials.
机构信息
Department of Anesthesiology, First Affiliated Hospital, School of Medicine, Shihezi University, Shihezi 832002, China.
Department of Urology, First Affiliated Hospital, School of Medicine, Shihezi University, Shihezi 832002, China.
出版信息
Biomed Res Int. 2018 Jul 4;2018:7474207. doi: 10.1155/2018/7474207. eCollection 2018.
OBJECTIVE
The study aims to systematically evaluate the clinical effect of gabapentin in the treatment of postherpetic neuralgia (PHN).
METHOD
Data were retrieved electronically from PubMed, Embase, CNKI, the China Biomedical Database, and the Library of Clinical Database, beginning from the time of inception to April 2017, in order to collect data on randomized controlled trials (RCTs) of gabapentin and placebo in PHN treatment.
RESULTS
A total of 11 RCTs (2376 people) were retrieved. The gabapentin group reported significantly reduced pain intensity [MD=-0.91, 95% CI -1.32 to -0.51, P<0.00001] compared with the placebo group. Those treated with gabapentin also experienced significantly improved sleep quality [SMD=-0.44, 95% CI -0.66 to -0.23, P<0.0001], but were more likely to experience incidence of adverse events, such as somnolence, dizziness, and peripheral edema. Results of the subgroup analysis showed that the source of heterogeneity may be related to the formulations of the drug.
CONCLUSION
Gabapentin can be used to effectively and safely treat PHN.
目的
本研究旨在系统评估加巴喷丁治疗带状疱疹后神经痛（PHN）的临床疗效。
方法
计算机检索 PubMed、Embase、中国知网（CNKI）、中国生物医学文献数据库（CBM）和临床循证数据库（Library of Clinical Database），搜集加巴喷丁与安慰剂治疗 PHN 的随机对照试验（RCT），检索时限均为建库至 2017 年 4 月。
结果
共纳入 11 项 RCT（2376 人）。与安慰剂组相比，加巴喷丁组疼痛强度显著降低[MD=-0.91，95%CI（-1.32，-0.51），P<0.00001]。加巴喷丁组睡眠质量也显著改善[SMD=-0.44，95%CI（-0.66，-0.23），P<0.0001]，但更易发生不良反应，如嗜睡、头晕和外周水肿。亚组分析结果显示，异质性的来源可能与药物剂型有关。
结论
加巴喷丁可有效且安全地治疗 PHN。
Zotero 插件