State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
Cancer Sci. 2018 Oct;109(10):3024-3031. doi: 10.1111/cas.13759. Epub 2018 Oct 3.
Fibroblast growth factor receptors (FGFR) play a significant role in both embryonic development and in adults. Upon binding with ligands, FGFR signaling is activated and triggers various downstream signal cascades that are implicated in diverse biological processes. Aberrant regulations of FGFR signaling are detected in numerous cancers. Although FGFR4 was discovered later than other FGFR, information on the involvement of FGFR4 in cancers has significantly increased in recent years. In this review, the recent findings in FGFR4 structure, signaling transduction, physiological function, aberrant regulations, and effects in cancers as well as its potential applications as an anticancer therapeutic target are summarized.
成纤维细胞生长因子受体（FGFR）在胚胎发育和成人中都发挥着重要作用。与配体结合后，FGFR 信号被激活，并触发涉及多种生物过程的各种下游信号级联。在许多癌症中都检测到 FGFR 信号的异常调节。尽管 FGFR4 的发现晚于其他 FGFR，但近年来关于 FGFR4 与癌症的关系的信息显著增加。在这篇综述中，总结了 FGFR4 的结构、信号转导、生理功能、异常调节以及在癌症中的作用及其作为抗癌治疗靶点的潜在应用的最新发现。
