结核菌素对淋巴细胞的非特异性刺激。
Nonspecific stimulation of lymphocytes by tuberculin.
作者信息
Sultzer B M, Nilsson B S, Kirschenbaum D
出版信息
Infect Immun. 1977 Mar;15(3):799-806. doi: 10.1128/iai.15.3.799-806.1977.
Abstract
Lymphocytes from uninfected, nonimmune mice can be stimulated to proliferate and produce antibody to diverse antigens in culture when exposed to the purified protein derivative of tuberculin or unheated tuberculin culture filtrate. Lymphocytes from numerous inbred strains of mice respond to tuberculin, but no true low responder strain has been found as yet. The evidence presented suggests that a subpopulation of B cells, which are distinct from those activated by lipopolysaccharide endotoxin, respond to tuberculin. The results of digestion experiments with insolubilized enzymes suggest that the nonspecific activating principles in tuberculin are protein.
摘要
当未感染、无免疫力的小鼠淋巴细胞暴露于结核菌素纯蛋白衍生物或未加热的结核菌素培养滤液时，可在培养物中被刺激增殖并产生针对多种抗原的抗体。许多近交系小鼠的淋巴细胞对结核菌素产生反应，但尚未发现真正的低反应品系。所提供的证据表明，与由脂多糖内毒素激活的B细胞不同的一个B细胞亚群对结核菌素产生反应。用不溶性酶进行的消化实验结果表明，结核菌素中的非特异性激活成分是蛋白质。
相似文献
1
Nonspecific stimulation of lymphocytes by tuberculin.结核菌素对淋巴细胞的非特异性刺激。
Infect Immun. 1977 Mar;15(3):799-806. doi: 10.1128/iai.15.3.799-806.1977.
2
Further studies on the activation of lymphocytes by endotoxin protein.关于内毒素蛋白激活淋巴细胞的进一步研究。
J Immunol. 1979 Apr;122(4):1329-34.
3
Inhibition of activated nonresponder C3H/HeJ lymphocytes by lipopolysaccharide endotoxin.脂多糖内毒素对活化的无反应性C3H/HeJ淋巴细胞的抑制作用。
Infect Immun. 1988 Dec;56(12):3040-5. doi: 10.1128/iai.56.12.3040-3045.1988.
4
Time-dependent inhibition of tuberculin-induced lymphocyte DNA synthesis by a serine protease inhibitor.丝氨酸蛋白酶抑制剂对结核菌素诱导的淋巴细胞DNA合成的时间依赖性抑制作用。
J Immunol. 1981 Jun;126(6):2209-14.
5
Genetic control of B-cell responses. I. Selective unresponsiveness to lipopolysaccharide.B细胞应答的遗传控制。I. 对脂多糖的选择性无反应性。
Scand J Immunol. 1975;4(2):139-43. doi: 10.1111/j.1365-3083.1975.tb02610.x.
6
7
Blastogenesis and lymphokine synthesis by T and B lymphocytes from patients with periodontal disease.牙周病患者T淋巴细胞和B淋巴细胞的母细胞生成及淋巴因子合成
Infect Immun. 1974 Oct;10(4):844-50. doi: 10.1128/iai.10.4.844-850.1974.
8
Genetic analysis of lymphocyte activation by lipopolysaccharide Endotoxin.脂多糖内毒素对淋巴细胞激活的遗传分析。
Infect Immun. 1976 Jun;13(6):1579-84. doi: 10.1128/iai.13.6.1579-1584.1976.
9
Effects of mitogens for mouse B lymphocytes on chicken lymphoid cells.小鼠B淋巴细胞有丝分裂原对鸡淋巴细胞的作用。
Immunology. 1975 Oct;29(4):697-707.
10
Endotoxin protein: a B-cell mitogen and polyclonal activator of C3H/HeJ lymphocytes.内毒素蛋白：一种C3H/HeJ淋巴细胞的B细胞促有丝分裂原和多克隆激活剂。
J Exp Med. 1976 Sep 1;144(3):821-7. doi: 10.1084/jem.144.3.821.
引用本文的文献
1
Transfer factor: a murine model.转移因子：一种小鼠模型。
Infect Immun. 1980 Jan;27(1):187-91. doi: 10.1128/iai.27.1.187-191.1980.
2
Leucocyte migration inhibition with Armadillo lepromin in human lymphocytes of healthy donors.犰狳麻风菌素对健康供体人淋巴细胞的白细胞迁移抑制作用。
Infection. 1978;6(1):5-7. doi: 10.1007/BF01641082.
3
Inhibition by human serum of lymphocyte proliferation stimulated by purified protein derivative of tuberculin and bacillus Calmette-Guérin.人血清对结核菌素纯蛋白衍生物和卡介苗刺激的淋巴细胞增殖的抑制作用。
Infect Immun. 1979 Sep;25(3):797-804. doi: 10.1128/iai.25.3.797-804.1979.
4
Specific and nonspecific resistance in mice immunized with irradiated Myobacterium leprae.用经辐照的麻风分枝杆菌免疫的小鼠的特异性和非特异性抵抗力
Infect Immun. 1978 Jun;20(3):692-7. doi: 10.1128/iai.20.3.692-697.1978.
5
Mycobacterial antigens: a review of their isolation, chemistry, and immunological properties.分枝杆菌抗原：其分离、化学性质及免疫学特性综述
Microbiol Rev. 1978 Mar;42(1):84-113. doi: 10.1128/mr.42.1.84-113.1978.
本文引用的文献
1
Immunization of dissociated spleen cell cultures from normal mice.对来自正常小鼠的脾细胞解离培养物进行免疫接种。
J Exp Med. 1967 Sep 1;126(3):423-42. doi: 10.1084/jem.126.3.423.
2
Clottable protein in Limulus; its localization and kinetics of its coagulation by endotoxin.鲎中的可凝蛋白；其定位及内毒素使其凝固的动力学。
Thromb Diath Haemorrh. 1968 Mar 31;19(1):186-97.
3
A simple method for the quantitation of submicrogram amounts of bacterial endotoxin.一种定量检测亚微克量细菌内毒素的简单方法。
Proc Soc Exp Biol Med. 1970 Mar;133(3):790-4. doi: 10.3181/00379727-133-34565.
4
Cellular recognition by mouse lymphocytes in vitro. I. Definition of a new technique and results of stimulation by phytohemagglutinin and specific antigens.小鼠淋巴细胞在体外的细胞识别。I. 一种新技术的定义以及植物血凝素和特异性抗原刺激的结果。
J Exp Med. 1970 Jun 1;131(6):1049-78. doi: 10.1084/jem.131.6.1049.
5
Antitrinitrophenyl (TNP) plaque assay. Primary response of Balb/c mice to soluble and particulate immunogen.抗三硝基苯基（TNP）空斑试验。Balb/c小鼠对可溶性和颗粒性免疫原的初次反应。
Proc Soc Exp Biol Med. 1969 Nov;132(2):575-81. doi: 10.3181/00379727-132-34264.
6
A receptor for antibody on B lymphocytes. I. Method of detection and functional significance.B淋巴细胞上的抗体受体。I. 检测方法及功能意义。
J Exp Med. 1972 Mar 1;135(3):610-26. doi: 10.1084/jem.135.3.610.
7
Genetic factors in leucocyte responses to endotoxin: further studies in mice.白细胞对内毒素反应中的遗传因素：小鼠的进一步研究
J Immunol. 1969 Jul;103(1):32-8.
8
The histogenesis of immunologically committed lymphocytes.免疫致敏淋巴细胞的组织发生
Cell Immunol. 1972 Apr;3(4):680-94. doi: 10.1016/0008-8749(72)90130-x.
9
Augmentation of PPD- and LPS-induced T-independent DNA synthesis in normal mouse spleen cells by leukocyte lysates from tuberculosis patients.结核病患者白细胞裂解物增强正常小鼠脾细胞中PPD和LPS诱导的非T细胞依赖性DNA合成。
Cell Immunol. 1974 Aug;13(2):196-206. doi: 10.1016/0008-8749(74)90238-x.
10
Age-related decline in thymic-independent immune function in a long-lived mouse strain.长寿小鼠品系中与年龄相关的非胸腺依赖性免疫功能衰退。
J Gerontol. 1974 May;29(3):261-8. doi: 10.1093/geronj/29.3.261.
Zotero 插件