School for Mental Health and Neuroscience (MHeNS), Department of Psychiatry and Neuropsychology, Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, The Netherlands.
School for Mental Health and Neuroscience (MHeNS), Department of Psychiatry and Neuropsychology, Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, The Netherlands.
Prog Mol Biol Transl Sci. 2018;158:15-27. doi: 10.1016/bs.pmbts.2018.04.009. Epub 2018 Jun 5.
Over the last years, interest in epigenetic mechanisms has strongly increased in the field of neuroscience. Neuroepigenetics has intensely evolved and now refers to the assessment of a variety of epigenetic marks which can be found across several regions of the healthy or diseased brain. These marks include DNA (hydroxy)methylation, a large diversity of post-translational histone modifications and an increasing number of non-coding RNAs. The present chapter aims to concisely summarize the techniques used to study these mechanisms in the brain and provides an overview of their current challenges along with future perspectives that will allow the field to move forward.
近年来，神经科学领域对表观遗传机制的兴趣大大增加。神经表观遗传学已经得到了深入的发展，现在指的是对可以在健康或患病大脑的多个区域中发现的各种表观遗传标记进行评估。这些标记包括 DNA（羟）甲基化、大量多样化的翻译后组蛋白修饰以及越来越多的非编码 RNA。本章旨在简明扼要地总结用于研究大脑中这些机制的技术，并概述其当前面临的挑战以及未来的展望，以推动该领域的发展。
