Geens Bart, Goossens Stijn, Li Jia, Van de Peer Yves, Vanden Broeck Jozef
Molecular Developmental Physiology and Signal Transduction, KU Leuven, Naamsestraat 59 box 2465, B-3000 Leuven, Belgium.
Department of Plant Biotechnology and Bioinformatics, Ghent University, Ghent, Belgium; VIB Center for Plant Systems Biology, VIB, Ghent, Belgium.
Mol Cell Endocrinol. 2024 May 1;585:112178. doi: 10.1016/j.mce.2024.112178. Epub 2024 Feb 9.
Hormones control developmental and physiological processes, often by regulating the expression of multiple genes simultaneously or sequentially. Crosstalk between hormones and epigenetics is pivotal to dynamically coordinate this process. Hormonal signals can guide the addition and removal of epigenetic marks, steering gene expression. Conversely, DNA methylation, histone modifications and non-coding RNAs can modulate regional chromatin structure and accessibility and regulate the expression of numerous (hormone-related) genes. Here, we provide a review of the interplay between the classical insect hormones, ecdysteroids and juvenile hormones, and epigenetics. We summarize the mode-of-action and roles of these hormones in post-embryonic development, and provide a general overview of epigenetic mechanisms. We then highlight recent advances on the interactions between these hormonal pathways and epigenetics, and their involvement in development. Furthermore, we give an overview of several 'omics techniques employed in the field. Finally, we discuss which questions remain unanswered and possible avenues for future research.
激素通常通过同时或相继调节多个基因的表达来控制发育和生理过程。激素与表观遗传学之间的相互作用对于动态协调这一过程至关重要。激素信号可以指导表观遗传标记的添加和去除，从而引导基因表达。相反，DNA甲基化、组蛋白修饰和非编码RNA可以调节局部染色质结构和可及性，并调节众多（与激素相关的）基因的表达。在此，我们综述了经典昆虫激素——蜕皮激素和保幼激素与表观遗传学之间的相互作用。我们总结了这些激素在胚后发育中的作用方式和作用，并对表观遗传机制进行了概述。然后，我们重点介绍了这些激素信号通路与表观遗传学之间相互作用的最新进展，以及它们在发育中的作用。此外，我们还概述了该领域所采用的几种“组学”技术。最后，我们讨论了哪些问题仍未得到解答以及未来可能的研究方向。
