脑转移瘤。

Brain Metastases.

机构信息

Department of Radiation Oncology, Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115, USA; Harvard Medical School, 25 Shattuck Street, Boston, MA 02115, USA.

Harvard Medical School, 25 Shattuck Street, Boston, MA 02115, USA; Center for Neuro-Oncology, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA 02215, USA; Department of Neurology, Brigham and Women's Hospital, Boston, MA 02115, USA.

出版信息

Neurol Clin. 2018 Aug;36(3):557-577. doi: 10.1016/j.ncl.2018.04.010. Epub 2018 Jun 18.

DOI:10.1016/j.ncl.2018.04.010

PMID:30072071

Abstract

Brain metastases from solid tumors are associated with increased morbidity and mortality. Standard treatment is local therapy with surgery and/or radiation therapy although there is increasing interest in systemic therapies that can control both intracranial and extracranial disease. We review the most recent data for local therapy and systemic therapy options. Active areas of research within radiation oncology include hippocampal sparing whole brain radiation therapy and stereotactic approaches for patients with more than 4 brain metastases. Newer targeted therapies with better central nervous system penetration and immunotherapies have demonstrated promising results in clinical trials of patients with brain metastases.

摘要

脑转移瘤与发病率和死亡率的增加有关。标准治疗是局部治疗，包括手术和/或放射治疗，尽管人们越来越关注能够控制颅内和颅外疾病的全身治疗方法。我们回顾了局部治疗和全身治疗选择的最新数据。放射肿瘤学领域的研究热点包括海马保护全脑放疗和立体定向治疗方法，适用于有超过 4 个脑转移瘤的患者。具有更好的中枢神经系统穿透性的新型靶向治疗和免疫疗法在脑转移瘤患者的临床试验中显示出了有前景的结果。