Liu Peiyi, Tang Yuhan, Guo Xiaoping, Zhu Xinhong, He Meian, Yuan Jing, Wang Youjie, Wei Sheng, Chen Weihong, Zhang Xiaomin, Miao Xiaoping, Yao Ping
Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety and the Ministry of Education (MOE) Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Institute of Occupational Medicine and the Ministry of Education (MOE) Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
J Am Soc Hypertens. 2018 Sep;12(9):660-670. doi: 10.1016/j.jash.2018.06.013. Epub 2018 Jul 3.
The relation between nonalcoholic fatty liver disease (NAFLD) and hypertension is not fully understood. To examine the effect of the change in NAFLD status on the risk of incident hypertension, and vice versa, 6704 eligible hypertension-free subjects and 9328 NAFLD-free subjects from the Dongfeng-Tongji cohort study at baseline were enrolled in the study. Among the hypertension-free subjects, development and persistence of NAFLD were associated with an increased odds ratio (OR) for incident hypertension (OR: 1.49, 95% confidence interval [CI]: 1.26-1.76, P < .0001; OR: 1.50, 95% CI: 1.27-1.78, P < .0001). However, the resolution of NAFLD was not a risk factor for incident hypertension. Among the NAFLD-free subjects, the risk of new-emerging NAFLD was robust for hypertension status both in no-yes (OR: 1.45, CI: 1.23-1.71) and yes-yes (OR: 1.61, CI: 1.35-1.92). Moreover, stratified analysis by diabetes and overweight/obese for the risk of incident NAFLD showed that incident hypertension (no-yes) and persistent hypertension (yes-yes) were associated with risk of incident NAFLD in subjects without diabetes or overweight/obesity. In the overweight/obese participants, persistent hypertension (yes-yes) was a risk factor for incident NAFLD (OR: 1.29, 95% CI: 1.01-1.64, P = .0387). Conclusively, incidence and persistence of NAFLD are associated with increased risk of hypertension, and vice versa.
非酒精性脂肪性肝病（NAFLD）与高血压之间的关系尚未完全明确。为了研究NAFLD状态变化对高血压发病风险的影响，反之亦然，本研究纳入了东风-同济队列研究基线时6704名符合条件的无高血压受试者和9328名无NAFLD受试者。在无高血压受试者中，NAFLD的发生和持续与高血压发病的比值比（OR）增加相关（OR：1.49，95%置信区间[CI]：1.26-1.76，P <.0001；OR：1.50，95%CI：1.27-1.78，P <.0001）。然而，NAFLD的缓解并非高血压发病的危险因素。在无NAFLD受试者中，无论高血压状态从无到有（OR：1.45，CI：1.23-1.71）还是从有到有（OR：1.61，CI：1.35-1.92），新发NAFLD的风险均显著增加。此外，按糖尿病和超重/肥胖对NAFLD发病风险进行分层分析显示，在无糖尿病或超重/肥胖的受试者中，高血压发病（无到有）和持续性高血压（有到有）与NAFLD发病风险相关。在超重/肥胖参与者中，持续性高血压（有到有）是NAFLD发病的危险因素（OR：1.29，95%CI：1.01-1.64，P = .0387）。总之，NAFLD的发生和持续与高血压风险增加相关，反之亦然。
