Department of Neurology, Philipps-University of Marburg, Marburg, Germany.
Chair of Geriatric Medicine, University Hospital Essen, Essen, Germany.
Muscle Nerve. 2018 Nov;58(5):681-687. doi: 10.1002/mus.26315. Epub 2018 Oct 3.
Cost of illness studies are essential to estimate societal costs of chronic inflammatory demyelinating polyneuropathy (CIDP) and identify cost-driving factors.
In total, 108 patients were recruited from 3 specialized neuroimmunological clinics. Costs were calculated for a 3-month period, including direct and indirect costs. The following outcomes were assessed: inflammatory neuropathy cause and treatment disability scale, Mini-Mental State Examination, Beck Depression Inventory, Charlson comorbidity index, EuroQol-5D, World Health Organization quality of life instrument, and socioeconomic status. Univariate and multivariate analyses were applied to identify cost-driving factors.
Total quarterly costs were €11,333. Direct costs contributed to 83% of total costs (€9,423), whereas indirect costs accounted for 17% (€1,910) of total costs. The cost of intravenous immunoglobulin (IVIg) was the main determinant of total costs (67%). Reduced health-related quality of life and depressive symptoms were identified as independent predictors of higher total costs.
CIDP is associated with high societal costs, mainly resulting from the cost of IVIg treatment. Muscle Nerve 58: 681-687, 2018.
疾病经济负担研究对于评估慢性炎症性脱髓鞘性多发性神经病（CIDP）的社会成本以及确定成本驱动因素至关重要。
共招募了来自 3 家专门的神经免疫诊所的 108 名患者。计算了为期 3 个月的直接和间接成本。评估了以下结果：炎症性神经病病因和治疗残疾量表、简易精神状态检查、贝克抑郁量表、Charlson 合并症指数、EuroQol-5D、世界卫生组织生活质量量表和社会经济状况。应用单变量和多变量分析来确定成本驱动因素。
总季度成本为 11333 欧元。直接成本占总成本的 83%（9423 欧元），而间接成本占 17%（1910 欧元）。静脉注射免疫球蛋白（IVIg）的成本是总费用的主要决定因素（67%）。健康相关生活质量降低和抑郁症状是总费用较高的独立预测因素。
CIDP 与高社会成本相关，主要是由于 IVIg 治疗的成本。肌肉神经 58: 681-687, 2018.
