Department of Neurosurgery, the First Affiliated Hospital of Guangxi Medical University, Nanning, 530021, China.
Department of Histology and Embryology, Guangxi Medical University, Nanning, 530021, China.
Curr Med Sci. 2018 Feb;38(1):19-25. doi: 10.1007/s11596-018-1842-0. Epub 2018 Mar 15.
Cancer testis antigens (CTAs) are attractive targets for tumor immunotherapy because of their tumor-specific expression. Since more than half of confirmed CTAs are located on the X-chromosome, we asked whether there is a link between CTA expression and X-chromosomes. Recent reports have shown that reactivation of the inactive X-chromosome, known as X-chromosome reactivation (XCR), a unique phenomenon that exists in many high-risk tumors in women, can transform the expression of many X-linked genes from monoallelic to biallelic. In this review, we discuss the link between CTA and XCR with the hopes of providing some novel insights into tumor biology.
癌症睾丸抗原（CTAs）因其肿瘤特异性表达而成为肿瘤免疫治疗的有吸引力的靶标。由于超过一半的已确认的 CTA 位于 X 染色体上，我们想知道 CTA 表达与 X 染色体之间是否存在联系。最近的报告表明，失活 X 染色体的重新激活，称为 X 染色体重新激活（XCR），是一种存在于许多女性高危肿瘤中的独特现象，它可以将许多 X 连锁基因的表达从单等位基因转变为双等位基因。在这篇综述中，我们讨论了 CTA 与 XCR 之间的联系，希望为肿瘤生物学提供一些新的见解。
