Department of Clinical Biochemistry, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Department of Molecular Medicine, National Institute of Genetic Engineering and Biotechnology, Tehran, Iran.
DNA Repair (Amst). 2018 Sep;69:63-72. doi: 10.1016/j.dnarep.2018.07.008. Epub 2018 Jul 20.
The cell cycle is controlled by precise mechanisms to prevent malignancies such as cancer, and the cell needs these tight and advanced controls. Cyclin dependent kinase inhibitor p27 (also known as KIP) is a factor that inhibits the progression of the cell cycle by using specific molecular mechanisms. The inhibitory effect of p27 on the cell cycle is mediated by CDKs inhibition. Other important functions of p27 include cell proliferation, cell differentiation and apoptosis. Post- translational modification of p27 by phosphorylation and ubiquitination respectively regulates interaction between p27 and cyclin/CDK complex and degradation of p27. In this review, we focus on the multiple function of p27 in cell cycle regulation, apoptosis, epigenetic modifications and post- translational modification, and briefly discuss the mechanisms and factors that have important roles in p27 functions.
细胞周期受精确机制控制，以防止癌症等恶性肿瘤的发生，而细胞需要这些紧密而先进的控制。细胞周期蛋白依赖性激酶抑制剂 p27（也称为 KIP）是一种通过特定分子机制抑制细胞周期进程的因子。p27 对细胞周期的抑制作用是通过抑制 CDK 来介导的。p27 的其他重要功能包括细胞增殖、细胞分化和细胞凋亡。p27 的磷酸化和泛素化等翻译后修饰分别调节 p27 与细胞周期蛋白/CDK 复合物的相互作用和 p27 的降解。在这篇综述中，我们重点讨论了 p27 在细胞周期调控、细胞凋亡、表观遗传修饰和翻译后修饰中的多种功能，并简要讨论了在 p27 功能中起重要作用的机制和因素。
