Long Yaolin, Li Yang, Xue Jin, Geng Wanqing, Ma Mingxia, Wang Xiaohui, Wang Li
Basic Medical Research Center, Shanxi Medical University, Taiyuan, Shanxi, China.
Department of Ophthalmology, Shanxi Medical University Second Affiliated Hospital, Taiyuan, Shanxi, China.
Front Physiol. 2025 Mar 12;16:1559313. doi: 10.3389/fphys.2025.1559313. eCollection 2025.
The SNX-BAR subfamily is a component of the sorting nexins (SNXs) superfamily. Distinct from other SNXs, which feature a PX domain for phosphoinositide binding, the SNX-BAR subfamily includes a BAR domain that induces membrane curvature. Members of the SNX-BAR subfamily work together to recognize and select specific cargo, regulate receptor signaling, and manage cargo sorting both with and without the involvement of sorting complexes. They play a crucial role in maintaining cellular homeostasis by directing intracellular cargo to appropriate locations through endo-lysosomal, autophagolysosomal, and ubiquitin-proteasome pathways. This subfamily thus links various protein homeostasis pathways. This review examines the established and hypothesized functions of the SNX-BAR subfamily, its role in intracellular protein sorting and stability, and explores the potential involvement of subfamily dysfunction in the pathophysiology of cardiovascular and neurodegenerative diseases.
分选连接蛋白X（SNX）-BAR亚家族是分选连接蛋白（SNXs）超家族的一个组成部分。与其他具有用于磷酸肌醇结合的PX结构域的SNX不同，SNX-BAR亚家族包含一个诱导膜曲率的BAR结构域。SNX-BAR亚家族的成员共同作用，以识别和选择特定的货物，调节受体信号传导，并在有或没有分选复合体参与的情况下管理货物分选。它们通过内吞溶酶体、自噬溶酶体和泛素-蛋白酶体途径将细胞内货物导向适当位置，从而在维持细胞内稳态中发挥关键作用。因此，该亚家族连接了各种蛋白质稳态途径。本综述研究了SNX-BAR亚家族已确定和推测的功能、其在细胞内蛋白质分选和稳定性中的作用，并探讨了亚家族功能障碍在心血管和神经退行性疾病病理生理学中的潜在参与情况。
