Department of Structural and Functional Biology, Institute of Biology, University of Campinas, UNICAMP, Campinas, SP, Brazil.
Department of Structural and Functional Biology, Institute of Biology, University of Campinas, UNICAMP, Campinas, SP, Brazil.
Int Immunopharmacol. 2018 Oct;63:84-93. doi: 10.1016/j.intimp.2018.07.031. Epub 2018 Aug 1.
Dendritic cells (DCs) are antigen-presenting cells with the ability to activate naïve T cells and direct the adaptive cellular immune response toward a specific profile. This is important, as different pathogens demand specific "profiles" of immune responses for their elimination. Such a goal is achieved depending on the maturation/activation status of DCs by the time of antigen presentation to T cells. Notwithstanding this, recent studies have shown that DCs alter their metabolic program to accommodate the functional changes in gene expression and protein synthesis that follow antigen recognition. In this review, we aim to summarize the data in the literature regarding the metabolic pathways involved with DC phenotypes and their functions.
树突状细胞 (DCs) 是具有抗原呈递能力的细胞，可以激活初始 T 细胞，并将适应性细胞免疫应答引导至特定的模式。这一点很重要，因为不同的病原体需要针对其清除的特定“模式”的免疫反应。通过在向 T 细胞呈递抗原时，根据 DCs 的成熟/激活状态，实现了这样的目标。尽管如此，最近的研究表明，DCs 会改变其代谢程序，以适应抗原识别后基因表达和蛋白质合成的功能变化。在这篇综述中，我们旨在总结文献中关于涉及 DC 表型及其功能的代谢途径的数据。
