Rahman M, Koh H, Primera M I, Del Greco F, Quintanilla A P
J Lab Clin Med. 1986 Apr;107(4):337-41.
We measured ouabain-sensitive and ouabain-resistant Na-K-adenosine triphosphatase (ATPase) activity in the red cells of 25 normotensive (average mean blood pressure [BP] 90.2 +/- 1.27 mm Hg) and 29 hypertensive subjects (average mean BP 115.3 +/- 2.45 mm Hg). Intracellular Na and K content were measured in 13 of the normotensive and 19 of the hypertensive subjects. All subjects were male, black, of comparable weight, and had not received antihypertensive medications for at least 30 days. Ouabain-sensitive ATPase activity was found significantly lower in the hypertensive than in the control group (140.2 +/- 11 and 97.6 +/- 7.6 nmol/mg/hr, respectively, P = 0.0008), whereas no significant difference in ouabain-insensitive ATPase was observed. Intracellular Na concentration was higher (9.47 vs. 7.24 mmol/L, P = 0.0144), and intracellular K concentration lower (82.8 vs. 88.8 mmol/L, P = 0.0425) in the hypertensive subjects. These results are consistent with diminished activity of the Na-K pump in black males with essential hypertension who have received no treatment.
我们测定了25名血压正常者（平均动脉血压[BP]90.2±1.27mmHg）和29名高血压患者（平均动脉血压115.3±2.45mmHg）红细胞中哇巴因敏感和哇巴因抵抗的钠钾三磷酸腺苷酶（ATP酶）活性。在13名血压正常者和19名高血压患者中测量了细胞内钠和钾含量。所有受试者均为男性黑人，体重相当，且至少30天未接受过降压药物治疗。发现高血压患者中哇巴因敏感的ATP酶活性显著低于对照组（分别为140.2±11和97.6±7.6nmol/mg/hr，P=0.0008），而哇巴因不敏感的ATP酶未观察到显著差异。高血压患者的细胞内钠浓度较高（9.47对7.24mmol/L，P=0.0144），细胞内钾浓度较低（82.8对88.8mmol/L，P=0.0425）。这些结果与未接受治疗的原发性高血压黑人男性钠钾泵活性降低一致。
