人类对极端环境条件的适应。
Human adaptation to extreme environmental conditions.
机构信息
The University of Utah Molecular Medicine Program, University of Utah, Salt Lake City, UT 84132, USA; Department of Integrative Biology, UC Berkeley, Berkeley, CA 94720, USA; Department of Statistics, UC Berkeley, Berkeley, CA 94720, USA.
Department of Integrative Biology, UC Berkeley, Berkeley, CA 94720, USA; Department of Statistics, UC Berkeley, Berkeley, CA 94720, USA; Natural History Museum of Denmark, University of Copenhagen, 1350 København K, Denmark.
出版信息
Curr Opin Genet Dev. 2018 Dec;53:77-82. doi: 10.1016/j.gde.2018.07.003. Epub 2018 Aug 1.
Abstract
Modern humans inhabit most of earth's harshest environments and display a wide array of lifestyles. Biological adaptations, in addition to technological innovations, have enabled these geographical and cultural explorations. The study of these adaptations helps not only to fundamentally understand our evolution as a species, but also may have increasing relevance as genomics transforms fields such as personalized medicine. Here we review three cultural and environmental shifts that have brought about adaptations in modern humans; the arctic, high altitudes, and a subsistence dependent on breath-hold diving.
摘要
现代人居住在地球大部分恶劣环境中，并展现出各种各样的生活方式。除了技术创新外，生物适应也使这些地理和文化探索成为可能。这些适应的研究不仅有助于从根本上理解我们作为一个物种的进化，而且随着基因组学改变个性化医疗等领域，它可能具有越来越重要的意义。在这里，我们回顾了三种使现代人适应的文化和环境变化：北极、高海拔和依赖闭气潜水的生存方式。
相似文献
1
Human adaptation to extreme environmental conditions.人类对极端环境条件的适应。
Curr Opin Genet Dev. 2018 Dec;53:77-82. doi: 10.1016/j.gde.2018.07.003. Epub 2018 Aug 1.
2
The Genomics of Human Local Adaptation.人类局部适应的基因组学。
Trends Genet. 2020 Jun;36(6):415-428. doi: 10.1016/j.tig.2020.03.006. Epub 2020 Apr 15.
3
Adaptations to local environments in modern human populations.现代人类群体对当地环境的适应性。
Curr Opin Genet Dev. 2014 Dec;29:1-8. doi: 10.1016/j.gde.2014.06.011. Epub 2014 Aug 15.
4
Convergent evolution in human and domesticate adaptation to high-altitude environments.人类和家养动物对高海拔环境适应的趋同进化。
Philos Trans R Soc Lond B Biol Sci. 2019 Jul 22;374(1777):20180235. doi: 10.1098/rstb.2018.0235. Epub 2019 Jun 3.
5
Physiological and Genetic Adaptations to Diving in Sea Nomads.海洋游牧民族的潜水生理和遗传适应性。
Cell. 2018 Apr 19;173(3):569-580.e15. doi: 10.1016/j.cell.2018.03.054.
6
Physiological and genomic evidence that selection on the transcription factor Epas1 has altered cardiovascular function in high-altitude deer mice.生理和基因组证据表明，高原鼠兔转录因子 Epas1 的选择改变了其心血管功能。
PLoS Genet. 2019 Nov 7;15(11):e1008420. doi: 10.1371/journal.pgen.1008420. eCollection 2019 Nov.
7
Genomic Analysis Reveals Hypoxia Adaptation in the Tibetan Mastiff by Introgression of the Gray Wolf from the Tibetan Plateau.基因组分析揭示了青藏高原灰狼的渗入导致藏獒的低氧适应。
Mol Biol Evol. 2017 Mar 1;34(3):734-743. doi: 10.1093/molbev/msw274.
8
Evidence for Adaptation to the Tibetan Plateau Inferred from Tibetan Loach Transcriptomes.从高原鳅转录组推断适应青藏高原的证据。
Genome Biol Evol. 2015 Oct 9;7(11):2970-82. doi: 10.1093/gbe/evv192.
9
Genetics of human origin and evolution: high-altitude adaptations.人类起源与进化的遗传学：高原适应
Curr Opin Genet Dev. 2016 Dec;41:8-13. doi: 10.1016/j.gde.2016.06.018. Epub 2016 Aug 6.
10
Whole-Genome Sequencing of Native Sheep Provides Insights into Rapid Adaptations to Extreme Environments.本地绵羊的全基因组测序为快速适应极端环境提供了见解。
Mol Biol Evol. 2016 Oct;33(10):2576-92. doi: 10.1093/molbev/msw129. Epub 2016 Jul 8.
引用本文的文献
1
Editorial: Genes, cells, and macroenvironments: regulating the immune response in extreme conditions.社论：基因、细胞与宏观环境：极端条件下的免疫反应调控
Front Immunol. 2025 Aug 25;16:1674347. doi: 10.3389/fimmu.2025.1674347. eCollection 2025.
2
Sex and environment shape cochlear sensitivity in human populations worldwide.性别和环境影响着全球人群的耳蜗敏感性。
Sci Rep. 2025 Mar 26;15(1):10475. doi: 10.1038/s41598-025-92763-6.
3
Analysis of the 10-day ultra-marathon using a predictive XG boost model.使用预测性XGboost模型对10天超马拉松进行分析。
BMC Res Notes. 2024 Dec 19;17(1):372. doi: 10.1186/s13104-024-07028-8.
4
Acute moderate normobaric hypoxia does not modify circulating thyroid hormone concentrations induced by 1 h of head-out cold-water immersion.急性适度常压缺氧不会改变 1 小时头高脚低温水浸导致的循环甲状腺激素浓度。
J Appl Physiol (1985). 2024 Jun 1;136(6):1400-1409. doi: 10.1152/japplphysiol.00061.2024. Epub 2024 Apr 25.
5
Can Tai Chi intervention improve the level of emotional regulation of crew members in the Controlled Ecological Life Support System?太极干预能否提高受控生态生命支持系统中机组人员的情绪调节水平？
Sports Med Health Sci. 2023 Jul 25;5(3):245-250. doi: 10.1016/j.smhs.2023.07.009. eCollection 2023 Sep.
6
Indigenous Knowledge and the Microbiome-Bridging the Disconnect between Colonized Places, Peoples, and the Unseen Influences That Shape Our Health and Well-Being.本土知识与微生物组——弥合被殖民的地方、人民与塑造我们健康和福祉的无形影响之间的脱节。
mSystems. 2023 Feb 23;8(1):e0087522. doi: 10.1128/msystems.00875-22. Epub 2023 Jan 25.
7
Novel Evidence Showing the Possible Effect of Environmental Variables on COVID-19 Spread.新证据表明环境变量对新冠病毒传播可能产生的影响。
Geohealth. 2022 Mar 1;6(3):e2021GH000502. doi: 10.1029/2021GH000502. eCollection 2022 Mar.
8
Molecular regulations of circadian rhythm and implications for physiology and diseases.生物钟的分子调控及其对生理和疾病的影响。
Signal Transduct Target Ther. 2022 Feb 8;7(1):41. doi: 10.1038/s41392-022-00899-y.
9
The Burden of Space Exploration on the Mental Health of Astronauts: A Narrative Review.太空探索对宇航员心理健康的负担：一项叙述性综述
Clin Neuropsychiatry. 2021 Oct;18(5):237-246. doi: 10.36131/cnfioritieditore20210502.
10
Upregulation of cathepsin L gene under mild cold conditions in young Japanese male adults.在轻度寒冷条件下，年轻日本男性成年人中组织蛋白酶 L 基因的上调。
J Physiol Anthropol. 2021 Oct 22;40(1):16. doi: 10.1186/s40101-021-00267-9.
本文引用的文献
1
Human local adaptation of the TRPM8 cold receptor along a latitudinal cline.人类冷感受器 TRPM8 沿着纬度梯度的局部适应。
PLoS Genet. 2018 May 3;14(5):e1007298. doi: 10.1371/journal.pgen.1007298. eCollection 2018 May.
2
Physiological and Genetic Adaptations to Diving in Sea Nomads.海洋游牧民族的潜水生理和遗传适应性。
Cell. 2018 Apr 19;173(3):569-580.e15. doi: 10.1016/j.cell.2018.03.054.
3
Associations of Omega-3 Fatty Acid Supplement Use With Cardiovascular Disease Risks: Meta-analysis of 10 Trials Involving 77 917 Individuals.ω-3 脂肪酸补充剂的使用与心血管疾病风险的关联：涉及 77917 人的 10 项试验的荟萃分析。
JAMA Cardiol. 2018 Mar 1;3(3):225-234. doi: 10.1001/jamacardio.2017.5205.
4
Natural Selection on Genes Related to Cardiovascular Health in High-Altitude Adapted Andeans.高海拔适应的安第斯人群中心血管健康相关基因的自然选择
Am J Hum Genet. 2017 Nov 2;101(5):752-767. doi: 10.1016/j.ajhg.2017.09.023.
5
Gain-of-function EGLN1 prolyl hydroxylase (PHD2 D4E:C127S) in combination with EPAS1 (HIF-2α) polymorphism lowers hemoglobin concentration in Tibetan highlanders.功能获得性EGLN1脯氨酰羟化酶（PHD2 D4E:C127S）与EPAS1（缺氧诱导因子-2α）多态性共同作用可降低藏族高原居民的血红蛋白浓度。
J Mol Med (Berl). 2017 Jun;95(6):665-670. doi: 10.1007/s00109-017-1519-3. Epub 2017 Feb 23.
6
TRP ion channels in thermosensation, thermoregulation and metabolism.瞬时受体电位（TRP）离子通道在温度感知、体温调节和新陈代谢中的作用
Temperature (Austin). 2015 May 26;2(2):178-87. doi: 10.1080/23328940.2015.1040604. eCollection 2015 Apr-Jun.
7
Greenlandic Inuit show genetic signatures of diet and climate adaptation.格陵兰因纽特人表现出饮食和气候适应的遗传特征。
Science. 2015 Sep 18;349(6254):1343-7. doi: 10.1126/science.aab2319.
8
A novel candidate region for genetic adaptation to high altitude in Andean populations.安第斯人群中遗传适应高海拔环境的一个新候选区域。
PLoS One. 2015 May 11;10(5):e0125444. doi: 10.1371/journal.pone.0125444. eCollection 2015.
9
A Selective Sweep on a Deleterious Mutation in CPT1A in Arctic Populations.北极人群中CPT1A基因有害突变的选择性清除
Am J Hum Genet. 2014 Nov 6;95(5):584-589. doi: 10.1016/j.ajhg.2014.09.016. Epub 2014 Oct 23.
10
Altitude adaptation in Tibetans caused by introgression of Denisovan-like DNA.藏族人群对高原环境的适应是由丹尼索瓦-like DNA 的渗入引起的。
Nature. 2014 Aug 14;512(7513):194-7. doi: 10.1038/nature13408. Epub 2014 Jul 2.
Zotero 插件