Department of Drug Informatics, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka, 814-0180, Japan.
Department of Physiology and Pharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka, 814-0180, Japan.
J Pharmacol Sci. 2018 Jun;137(2):233-236. doi: 10.1016/j.jphs.2018.05.009. Epub 2018 Jun 7.
The role of the GABA receptor in the anterior cingulate cortex (ACC) of neuropathic pain is unclear. Injection of a GABA receptor antagonist CGP35348 into the ACC induced mechanical hypersensitivity in normal rats. Activation of the GABA receptor injected by a GABA receptor agonist baclofen into the ACC attenuated mechanical hypersensitivity in partial sciatic nerve ligation (PSNL) rats. Co-microinjection of CGP35348 with a muscarinic M1 receptor agonist McN-A-343 into the ACC significantly inhibited McN-A-343-induced antihypersensitivity in PSNL rats. These results suggest that the GABA receptor in the ACC contributes to mechanical hypersensitivity and is involved in muscarinic M receptor-mediated antihypersensitivity.
GABA 受体在前扣带回皮层（ACC）中在神经性疼痛中的作用尚不清楚。将 GABA 受体拮抗剂 CGP35348 注射到 ACC 中会诱导正常大鼠的机械性痛敏。将 GABA 受体激动剂巴氯芬注射到 ACC 中激活 GABA 受体可减轻部分坐骨神经结扎（PSNL）大鼠的机械性痛敏。将 CGP35348 与毒蕈碱 M1 受体激动剂 McN-A-343 共同微注射到 ACC 中，可显著抑制 McN-A-343 在 PSNL 大鼠中的抗痛敏作用。这些结果表明，ACC 中的 GABA 受体有助于机械性痛敏，并参与了毒蕈碱 M 受体介导的抗痛敏作用。
