GABA 受体参与部分结扎坐骨神经模型扣带回前部的抗敏作用。
Involvement of GABA receptor in the antihypersensitive effect in anterior cingulate cortex of partial sciatic nerve ligation model.
机构信息
Department of Drug Informatics, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka, 814-0180, Japan.
Department of Physiology and Pharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka, 814-0180, Japan.
出版信息
J Pharmacol Sci. 2018 Jun;137(2):233-236. doi: 10.1016/j.jphs.2018.05.009. Epub 2018 Jun 7.
The role of the GABA receptor in the anterior cingulate cortex (ACC) of neuropathic pain is unclear. Injection of a GABA receptor antagonist CGP35348 into the ACC induced mechanical hypersensitivity in normal rats. Activation of the GABA receptor injected by a GABA receptor agonist baclofen into the ACC attenuated mechanical hypersensitivity in partial sciatic nerve ligation (PSNL) rats. Co-microinjection of CGP35348 with a muscarinic M1 receptor agonist McN-A-343 into the ACC significantly inhibited McN-A-343-induced antihypersensitivity in PSNL rats. These results suggest that the GABA receptor in the ACC contributes to mechanical hypersensitivity and is involved in muscarinic M receptor-mediated antihypersensitivity.
GABA 受体在前扣带回皮层（ACC）中在神经性疼痛中的作用尚不清楚。将 GABA 受体拮抗剂 CGP35348 注射到 ACC 中会诱导正常大鼠的机械性痛敏。将 GABA 受体激动剂巴氯芬注射到 ACC 中激活 GABA 受体可减轻部分坐骨神经结扎（PSNL）大鼠的机械性痛敏。将 CGP35348 与毒蕈碱 M1 受体激动剂 McN-A-343 共同微注射到 ACC 中，可显著抑制 McN-A-343 在 PSNL 大鼠中的抗痛敏作用。这些结果表明，ACC 中的 GABA 受体有助于机械性痛敏，并参与了毒蕈碱 M 受体介导的抗痛敏作用。
Zotero 插件