Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland.
Curr Top Behav Neurosci. 2022;52:213-239. doi: 10.1007/7854_2020_130.
A substantial fraction of the human population suffers from chronic pain states, which often cannot be sufficiently treated with existing drugs. This calls for alternative targets and strategies for the development of novel analgesics. There is substantial evidence that the G protein-coupled GABA receptor is involved in the processing of pain signals and thus has long been considered a valuable target for the generation of analgesics to treat chronic pain. In this review, the contribution of GABA receptors to the generation and modulation of pain signals, their involvement in chronic pain states as well as their target suitability for the development of novel analgesics is discussed.
相当一部分人群患有慢性疼痛状态，而现有药物往往无法充分治疗这些疾病。这就需要寻找新的靶点和策略来开发新型的镇痛药。有大量证据表明，G 蛋白偶联 GABA 受体参与疼痛信号的处理，因此长期以来一直被认为是产生镇痛药治疗慢性疼痛的有价值的靶点。在这篇综述中，讨论了 GABA 受体在产生和调节疼痛信号中的作用、它们在慢性疼痛状态中的参与以及它们作为新型镇痛药开发的靶标适宜性。
