Barsotti G, Lazzeri M, Cristofano C, Cerri M, Lupetti S, Giovannetti S
Miner Electrolyte Metab. 1986;12(2):103-6.
Metabolic acidosis was corrected within 1 h in 7 chronic anuric uremic patients on maintenance hemodialysis and, in the course of a week, in 11 other patients on conservative therapy. These patients were on a diet supplying constant amounts of phosphate throughout the duration of the study. In the former group the intravenous infusion of sodium bicarbonate was used, and, in the latter, the oral administration of sodium citrate. In both groups serum phosphate was found to decrease significantly. In the patients on conservative therapy, phosphaturia also had significantly decreased while no changes occurred in their daily fecal loss of phosphate that was measured in 3 patients. These findings indicate that metabolic acidosis is one of the causes of hyperphosphatemia in chronic uremic patients.
7例维持性血液透析的慢性无尿尿毒症患者在1小时内代谢性酸中毒得到纠正，另外11例接受保守治疗的患者在一周内代谢性酸中毒得到纠正。在整个研究期间，这些患者的饮食中磷的供应量保持恒定。前一组采用静脉输注碳酸氢钠，后一组采用口服柠檬酸钠。两组患者的血清磷均显著下降。在接受保守治疗的患者中，尿磷排泄也显著减少，而3例患者的每日粪便磷丢失量未发生变化。这些发现表明，代谢性酸中毒是慢性尿毒症患者高磷血症的原因之一。
