Department of Chemistry and Molecular Biology , University of Gothenburg , SE-412 96 Gothenburg , Sweden.
Department of Chemistry and Chemical Engineering, Physical Chemistry , Chalmers University of Technology , SE-412 96 Gothenburg , Sweden.
Org Lett. 2018 Aug 17;20(16):4875-4879. doi: 10.1021/acs.orglett.8b02014. Epub 2018 Aug 6.
A set of azoheteroarenes have been synthesized with Buchwald-Hartwig coupling and microwave-assisted O oxidation as the key steps. Several compounds exhibit good to excellent photoswitching properties (high switching efficiency, good fatigue resistance, and thermal stability of Z-isomer) relevant for photocontrolled applications, which pave the way for use in photopharmacology.
已通过 Buchwald-Hartwig 偶联和微波辅助 O 氧化反应合成了一系列偶氮杂芳族化合物。几种化合物表现出良好至优异的光致开关性能（高开关效率、良好的抗疲劳性和 Z-异构体的热稳定性），与光控应用相关，为在光药理学中的应用铺平了道路。
