Mohammed A K, Danysz W, Ogren S O, Archer T
Neurosci Lett. 1986 Feb 28;64(2):139-44. doi: 10.1016/0304-3940(86)90089-3.
Male rats were given 6-hydroxydopamine-induced lesions of the locus coeruleus (LC) or the dorsal noradrenergic bundle (DNAB), prior to the measurement of locomotor and rearing activity induced by D-amphetamine. The increased locomotor activity induced by D-amphetamine (1.8 mg/kg) was significantly attenuated by both the LC and the DNAB lesions. The stimulatory effect of the 7.2 mg/kg dose of amphetamine was attenuated by the LC lesion, whereas the DNAB lesion potentiated this effect. The LC lesion also attenuated rearing induced by the 7.2 mg/kg dose of amphetamine. These results suggest some involvement of central noradrenergic neurons in the activity induced by amphetamine in the rat.
在测量由右旋苯丙胺诱导的运动和竖毛活动之前，给雄性大鼠注射6-羟基多巴胺以损伤蓝斑（LC）或背侧去甲肾上腺素能束（DNAB）。由右旋苯丙胺（1.8mg/kg）诱导的运动活动增加被LC和DNAB损伤均显著减弱。7.2mg/kg剂量的苯丙胺的刺激作用被LC损伤减弱，而DNAB损伤增强了这种作用。LC损伤也减弱了7.2mg/kg剂量的苯丙胺诱导的竖毛行为。这些结果表明中枢去甲肾上腺素能神经元参与了大鼠中由苯丙胺诱导的活动。
