Key Laboratory for Green Organic Synthesis and Application of Hunan Province, Key Laboratory of Environmentally Friendly Chemistry and Application of Ministry of Education, College of Chemistry , Xiangtan University , Xiangtan 411105 , China.
Org Lett. 2018 Aug 17;20(16):4917-4920. doi: 10.1021/acs.orglett.8b02049. Epub 2018 Aug 6.
A concise access to thiophene-fused polycyclic π-conjugated systems is described. Methyl aromatic ketoxime acetates, aromatic aldehydes, and elemental sulfur are efficiently assembled in a facile copper-catalytic system through a novel cascade bis-heteroannulation to afford a fused thieno[3,2- d]thiazole motif. The robust nature of this reaction system is reflected by the remarkable simplicity-to-complexity transformation in a one-pot operation, high-yield gram-scale synthesis, and potential applications on the synthesis of high-performance optoelectronic materials.
描述了一种简洁的噻吩稠合多环π共轭体系的方法。通过新颖的双杂环并合一锅法，在简便的铜催化体系中，甲氧基芳酮乙酸酯、芳醛和元素硫高效地组装在一起，得到稠合噻吩[3,2- d]噻唑基序。该反应体系的稳健性体现在一锅操作中显著的从简单到复杂的转化、高产克级规模合成以及在高性能光电材料合成中的潜在应用。
