在无金属条件下，以硫粉为硫源，布朗斯特酸促进噻唑的合成。
Brønsted acid-promoted thiazole synthesis under metal-free conditions using sulfur powder as the sulfur source.
作者信息
Ni Penghui, Tan Jing, Li Rong, Huang Huawen, Zhang Feng, Deng Guo-Jun
机构信息
Key Laboratory for Green Organic Synthesis and Application of Hunan Province, Key Laboratory of Environmentally Friendly Chemistry and Application of Ministry of Education, College of Chemistry, Xiangtan University Xiangtan 411105 China
College of Science, Hunan Agricultural University Changsha 410128 China
出版信息
RSC Adv. 2020 Jan 23;10(7):3931-3935. doi: 10.1039/c9ra09656f. eCollection 2020 Jan 22.
A Brønsted acid-promoted sulfuration/annulation reaction for the one-pot synthesis of bis-substituted thiazoles from benzylamines, acetophenones, and sulfur powder has been developed. One C-N bond and multi C-S bonds were selectively formed in one pot. The choice of the Brønsted acid was the key to the high efficiency of this transformation under metal-free conditions.
已开发出一种布朗斯特酸促进的硫化/环化反应，用于从苄胺、苯乙酮和硫粉一锅法合成双取代噻唑。在一锅中选择性地形成了一个C-N键和多个C-S键。布朗斯特酸的选择是在无金属条件下实现这种高效转化的关键。
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