Foster R S
J Natl Cancer Inst. 1977 May;58(5):1503-5. doi: 10.1093/jnci/58.5.1503.
Mice with advanced lymphoid leukemia have elevated peripheral blood granulocytes and elevated serum colony-stimulating activity, which promotes the in vitro growth of granulocyte and/or macrophage colonies. The number of bone marrow precursor cells of the in vitro granulocyte and/or macrophage colonies varied from normal to 10% of normal. The elevation of colony-stimulating activity correlated best with a combination of increased blood granulocytes and a deficiency of bone marrow precursor cells, which suggested that colony-stimulating activity is a leukopoietin that increases the efficiency and rate of production of granulocytes.
患有晚期淋巴细胞白血病的小鼠外周血粒细胞数量升高，血清集落刺激活性增强，这促进了粒细胞和/或巨噬细胞集落在体外的生长。体外粒细胞和/或巨噬细胞集落的骨髓前体细胞数量从正常到正常水平的10%不等。集落刺激活性的升高与血液粒细胞增加和骨髓前体细胞缺乏的组合最为相关，这表明集落刺激活性是一种白细胞生成素，可提高粒细胞的产生效率和速率。
