School of Nursing, College of Medicine, National Taiwan University, Taipei 10051, Taiwan.
Department of Psychology, Azusa Pacific University, Azusa, CA 91702, USA.
Int J Environ Res Public Health. 2018 Aug 5;15(8):1660. doi: 10.3390/ijerph15081660.
Congenital heart disease (CHD) is the leading cause of death in children, and is affected by genetic and environmental factors. To investigate the association of air pollution with () polymorphisms and the risk of CHD, we included 58 study groups of children and parents, with 12,347 cases and 18,106 controls worldwide. Both C677T (rs 1801133) and A1298C (rs 1801131) gene polymorphisms were risks for CHD in children with transgenerational effects from their parents. Countries with greater risks of CHD with a pooled risk ratio (RR) > 2 from 677 polymorphisms included Germany, Portugal, China, and Egypt for children; and Brazil, Puerto Rico, Mexico, China, and Egypt for mothers. Whereas, countries with greater risk of CHD with RR > 2 from 1298 polymorphisms included Taiwan, Turkey, and Egypt for children; and Brazil, China, and Egypt for mothers. Additionally, meta-prediction analysis revealed that the percentages of 677TT and TT plus CT polymorphisms together were increased in countries with higher levels of air pollution, with a trend of increased CHD risks with higher levels of air pollution for children ( = 0.07). Our findings may have significant implications for inflammatory pathways in association with polymorphisms and future intervention studies to correct for folate-related enzyme deficits resultied from polymorphisms to prevent CHDs for future generations.
先天性心脏病（CHD）是儿童死亡的主要原因，受遗传和环境因素的影响。为了研究空气污染与 MTHFR 基因多态性与 CHD 风险的关系，我们纳入了全球 58 个儿童及其父母的研究组，共有 12347 例病例和 18106 例对照。C677T（rs1801133）和 A1298C（rs1801131）基因多态性均与儿童的 CHD 风险相关，具有跨代效应。677 多态性的汇总风险比（RR）>2 的 CHD 风险较高的国家包括德国、葡萄牙、中国和埃及（儿童）；巴西、波多黎各、墨西哥、中国和埃及（母亲）。而 1298 多态性的 RR>2 的 CHD 风险较高的国家包括中国台湾、土耳其和埃及（儿童）；巴西、中国和埃及（母亲）。此外，元预测分析显示，空气污染水平较高的国家 677TT 和 TT 加 CT 多态性的百分比增加，儿童的 CHD 风险随着空气污染水平的升高而增加（ = 0.07）。我们的研究结果可能对与 MTHFR 基因多态性相关的炎症途径具有重要意义，并为未来的干预研究提供参考，以纠正由于 MTHFR 基因多态性导致的叶酸相关酶缺陷，从而预防后代的 CHD。
