Yu Xiaomin, An Xin, Lu Hui, Wang Xingting, Jiang Yan
College of Life Science and Technology, Xinjiang University, Urumqi 830046, China.
Wei Sheng Yan Jiu. 2018 May;47(3):432-436.
To study hypoglycemic effects of different mulberry leaf extracts on diabetic mice.
STZ-induced diabetic mice were intragastricly administrated with different mulberry leaf extracts( water extracts: 800 mg/kg, ethanol extracts: 500 mg/kg, water extracts + ethanol extracts: low dose 150 mg/kg, high dose300 mg/kg) and positive control group( melbine: 227. 5 mg/kg). Four weeks later, serum glucose levels, insulin levels, antioxidase activities were tested. Liver and pancreas pathological changes were observed by HE staining.
Compared with model group, each mulberry leaf extracts group could decrease serum glucose and insulin levels and increase antioxidase activities. The mixture of water extracts and ethanol extracts at high dose showed the most obvious effects. In this group, serum glucose levels, insulin levels, insulin resistance index and insulin sensitivity index were 61. 0%, 64. 1%, 42. 9% and 1. 18 times of those in the model group( P < 0. 05), and no significant differences were found between this group and the positive group( P > 0. 05).
The mixture of mulberry leaf water and ethanol extracts showed synergistic hypoglycemic effects by increasing antioxidase activities, repairing pancrea and liver oxidative damages, and improving insulin resistance status.
研究不同桑叶提取物对糖尿病小鼠的降血糖作用。
将链脲佐菌素诱导的糖尿病小鼠分别灌胃给予不同的桑叶提取物（水提取物：800毫克/千克，乙醇提取物：500毫克/千克，水提取物+乙醇提取物：低剂量150毫克/千克，高剂量300毫克/千克）以及阳性对照组（美比达：227.5毫克/千克）。四周后，检测血清葡萄糖水平、胰岛素水平、抗氧化酶活性。通过苏木精-伊红染色观察肝脏和胰腺的病理变化。
与模型组相比，各桑叶提取物组均可降低血清葡萄糖和胰岛素水平，并提高抗氧化酶活性。高剂量水提取物与乙醇提取物的混合物效果最为明显。该组血清葡萄糖水平、胰岛素水平、胰岛素抵抗指数和胰岛素敏感指数分别为模型组的61.0%、64.1%、42.9%和1.18倍（P<0.05），且该组与阳性组之间无显著差异（P>0.05）。
桑叶水提取物与乙醇提取物的混合物通过提高抗氧化酶活性、修复胰腺和肝脏氧化损伤以及改善胰岛素抵抗状态，显示出协同降血糖作用。
