Hattami Sajjad, Khalatbari Behzad, Karimi Mona
Department of Plastic Surgery, Iran University of Medical Sciences, Tehran, Iran.
Burn and Wound Healing Research Center, Department of Plastic Surgery, Shiraz University of Medical Sciences, Shiraz, Iran.
World J Plast Surg. 2018 May;7(2):198-203.
One of the weaknesses of recovering the skin defects by tissue expander device is that it needs relatively long time and it has complications. Since verapamil gel reduces the production of these capsules around silicone prosthesis and reduces the formation of collagen in the capsule areas. The aim of this study was to examine the effect of verapamil gel on efficiency of tissue expander device.
Twenty patients were allocated equally into control and case groups based on age, sex, and location of the device. In both groups, the devices were placed in the areas needed and the conditions were identical. During the first operation, the length and width of the flaps and the initial size of prosthesis were determined. In the case group, verapamil gel was used daily, while a hydrogel was used as placebo locally in the control group. Then, other indicators were assessed.
Verapamil gel had no impact on the length, width, area, and size of placed flaps. The opening degree and necrosis of tissue were not improved in patients of case group after using the gel. The effect of verapamil gel in different age groups and gender of people had no significant difference.
Verapamil gel was shown not to have any significant impact on efficiency of tissue expander device.
使用组织扩张器修复皮肤缺损的缺点之一是所需时间相对较长且存在并发症。由于维拉帕米凝胶可减少硅胶假体周围这些包膜的产生，并减少包膜区域胶原蛋白的形成。本研究的目的是探讨维拉帕米凝胶对组织扩张器效能的影响。
根据年龄、性别和扩张器位置将20例患者平均分为对照组和病例组。两组均将扩张器放置于所需部位，条件相同。在第一次手术时，确定皮瓣的长度和宽度以及假体的初始尺寸。病例组每日使用维拉帕米凝胶，而对照组局部使用水凝胶作为安慰剂。然后，评估其他指标。
维拉帕米凝胶对所放置皮瓣的长度、宽度、面积和尺寸没有影响。使用凝胶后病例组患者组织的张开程度和坏死情况未得到改善。维拉帕米凝胶在不同年龄组和性别人群中的效果无显著差异。
维拉帕米凝胶对组织扩张器的效能没有显著影响。
