碱中毒对大鼠葡萄糖介导的胰岛素释放的影响。

The effect of alkalosis on the glucose-mediated insulin release by the rat.

作者信息

Ballina J C, Pérez Jimeno N, Puche R C

出版信息

Acta Physiol Pharmacol Latinoam. 1985;35(3):267-73.

Abstract

Bicarbonate loaded (alkalotic) rats had reduced plasma phosphate and ionized Ca concentrations and increased urinary cAMP excretion, phosphate clearance and pancreatic tissue uptake of extracellular calcium, all known effects of increased parathyroid hormone (PTH) secretion. Total insulin secretion after glucose challenge was enhanced in these animals. The response of alkalotic thyroparathyroidectomized rats, on the other hand, suggested exhaustion or inhibition of insulin secretion. The hypothesis is advanced that PTH, enhancing the permeability to calcium of the beta-cell membrane, compensated the effect of decreased calcium concentration in the extracellular fluid caused by alkalosis. PTH appears instrumental for homeostatic adjustments of insulin secretion.

摘要

碳酸氢盐负荷（碱中毒）大鼠的血浆磷酸盐和离子钙浓度降低，尿中cAMP排泄、磷酸盐清除率以及胰腺组织对细胞外钙的摄取增加，这些都是甲状旁腺激素（PTH）分泌增加的已知效应。在这些动物中，葡萄糖激发后的总胰岛素分泌增强。另一方面，碱中毒的甲状腺甲状旁腺切除大鼠的反应表明胰岛素分泌耗竭或受到抑制。提出的假说是，PTH增强了β细胞膜对钙的通透性，补偿了碱中毒导致的细胞外液钙浓度降低的影响。PTH似乎对胰岛素分泌的稳态调节起作用。