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1
Nerve growth factor-mediated induction of tyrosine hydroxylase in a clonal pheochromocytoma cell line.神经生长因子介导的克隆性嗜铬细胞瘤细胞系中酪氨酸羟化酶的诱导
Proc Natl Acad Sci U S A. 1978 Sep;75(9):4587-90. doi: 10.1073/pnas.75.9.4587.
2
Epidermal growth factor induces tyrosine hydroxylase in a clonal pheochromocytoma cell line, PC-G2.表皮生长因子在克隆性嗜铬细胞瘤细胞系PC-G2中诱导酪氨酸羟化酶的产生。
J Cell Biol. 1980 Mar;84(3):495-500. doi: 10.1083/jcb.84.3.495.
3
Selective enzyme induction in a nerve growth factor-responsive pheochromocytoma cell line (PC 12).在一种对神经生长因子有反应的嗜铬细胞瘤细胞系（PC 12）中的选择性酶诱导。
Brain Res. 1978 Oct 6;154(1):186-90. doi: 10.1016/0006-8993(78)91070-3.
4
Nerve growth factor-mediated stimulation of tyrosine hydroxylase activity in a clonal rat pheochromocytoma cell line.神经生长因子介导的对大鼠嗜铬细胞瘤克隆细胞系中酪氨酸羟化酶活性的刺激作用。
Brain Res. 1981 Oct 19;222(2):225-33. doi: 10.1016/0006-8993(81)91029-5.
5
Translation of tyrosine hydroxylase from poly(A)-mRNA in pheochromocytoma cells is enhanced by dexamethasone.在嗜铬细胞瘤细胞中，地塞米松可增强酪氨酸羟化酶从多聚腺苷酸信使核糖核酸（poly(A)-mRNA）的翻译。
Proc Natl Acad Sci U S A. 1981 Feb;78(2):1269-73. doi: 10.1073/pnas.78.2.1269.
6
Permissive action of glucocorticoids in induction of tyrosine hydroxylase by nerve growth factor in a pheochromocytoma cell line.糖皮质激素在嗜铬细胞瘤细胞系中对神经生长因子诱导酪氨酸羟化酶的允许作用。
Brain Res. 1980 Jul 7;193(1):304-8. doi: 10.1016/0006-8993(80)90972-5.
7
Induction of tyrosine hydroxylase by cyclic AMP and glucocorticoids in a rat pheochromocytoma cell line: effect of the inducing agents alone or in combination on the enzyme levels and rate of synthesis of tyrosine hydroxylase.环磷酸腺苷（cAMP）和糖皮质激素对大鼠嗜铬细胞瘤细胞系酪氨酸羟化酶的诱导作用：单独或联合诱导剂对酪氨酸羟化酶水平及合成速率的影响
Mol Pharmacol. 1986 Nov;30(5):486-96.
8
Induction of mRNA for tyrosine hydroxylase by cyclic AMP and glucocorticoids in a rat pheochromocytoma cell line: evidence for the regulation of tyrosine hydroxylase synthesis by multiple mechanisms in cells exposed to elevated levels of both inducing agents.环磷酸腺苷（cAMP）和糖皮质激素在大鼠嗜铬细胞瘤细胞系中诱导酪氨酸羟化酶mRNA的表达：在同时暴露于两种诱导剂高水平的细胞中，酪氨酸羟化酶合成受多种机制调控的证据。
Mol Pharmacol. 1986 Nov;30(5):497-503.
9
Regulation of the multiple forms of dopamine beta-hydroxylase by nerve growth factor, dexamethasone, and dibutyryl cyclic AMP in the PC12 pheochromocytoma cell line.神经生长因子、地塞米松和二丁酰环磷腺苷对PC12嗜铬细胞瘤细胞系中多巴胺β-羟化酶多种形式的调控
J Biol Chem. 1983 Jun 25;258(12):7819-23.
10
Monoclonal antibodies to tyrosine hydroxylase from rat pheochromocytoma PC12h cells with special reference to nerve growth factor-mediated increase of the immunoprecipitable enzymes.来自大鼠嗜铬细胞瘤PC12h细胞的酪氨酸羟化酶单克隆抗体，特别提及神经生长因子介导的免疫沉淀酶增加。
Neurosci Res. 1984 Aug;1(4):253-63. doi: 10.1016/s0168-0102(84)80004-8.

引用本文的文献

1
Genes for catecholamine biosynthesis: cloning by expression and identification of the cDNA for rat dopamine beta-hydroxylase.儿茶酚胺生物合成相关基因：通过表达进行克隆并鉴定大鼠多巴胺β-羟化酶的cDNA
Proc Natl Acad Sci U S A. 1983 Apr;80(8):2161-5. doi: 10.1073/pnas.80.8.2161.
2
Identification of cDNA clones coding for rat tyrosine hydroxylase antigen.编码大鼠酪氨酸羟化酶抗原的cDNA克隆的鉴定。
Proc Natl Acad Sci U S A. 1982 Jun;79(12):3881-5. doi: 10.1073/pnas.79.12.3881.
3
Epidermal growth factor induces tyrosine hydroxylase in a clonal pheochromocytoma cell line, PC-G2.表皮生长因子在克隆性嗜铬细胞瘤细胞系PC-G2中诱导酪氨酸羟化酶的产生。
J Cell Biol. 1980 Mar;84(3):495-500. doi: 10.1083/jcb.84.3.495.
4
Involvement of the nerve growth factor-inducible large external glycoprotein (NILE) in neurite fasciculation in primary cultures of rat brain.神经生长因子诱导的大细胞外糖蛋白（NILE）在大鼠脑原代培养物中神经突束状化中的作用。
Proc Natl Acad Sci U S A. 1985 Feb;82(4):1276-80. doi: 10.1073/pnas.82.4.1276.
5
Upstream regions of the human cardiac actin gene that modulate its transcription in muscle cells: presence of an evolutionarily conserved repeated motif.人类心肌肌动蛋白基因上游区域对其在肌肉细胞中转录的调控：存在一个进化上保守的重复基序。
Mol Cell Biol. 1986 Jun;6(6):2125-36. doi: 10.1128/mcb.6.6.2125-2136.1986.
6
Transcriptional regulation of the tyrosine hydroxylase gene by glucocorticoid and cyclic AMP.糖皮质激素和环磷酸腺苷对酪氨酸羟化酶基因的转录调控
Proc Natl Acad Sci U S A. 1987 Jun;84(11):3550-4. doi: 10.1073/pnas.84.11.3550.
7
Identification and cell type specificity of the tyrosine hydroxylase gene promoter.酪氨酸羟化酶基因启动子的鉴定及细胞类型特异性
Nucleic Acids Res. 1987 Mar 11;15(5):2363-84. doi: 10.1093/nar/15.5.2363.
8
Regulation of the differentiation of PC12 pheochromocytoma cells.PC12嗜铬细胞瘤细胞分化的调控
Environ Health Perspect. 1989 Mar;80:127-42. doi: 10.1289/ehp.8980127.
9
Regulation of nerve growth factor receptor gene expression by nerve growth factor in the developing peripheral nervous system.发育中的周围神经系统中神经生长因子对神经生长因子受体基因表达的调控。
J Cell Biol. 1991 Jan;112(2):303-12. doi: 10.1083/jcb.112.2.303.
10
Growth regulation by nerve growth factor.神经生长因子对生长的调节作用。
Mol Cell Biochem. 1979 Dec 14;28(1-3):67-91. doi: 10.1007/BF00223360.

本文引用的文献

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The apparent ionization constants of the adenosinephosphates and related compounds.腺苷磷酸及相关化合物的表观电离常数。
J Biol Chem. 1951 Nov;193(1):425-34.
2
Essential role of the nerve growth factor in the survival and maintenance of dissociated sensory and sympathetic embryonic nerve cells in vitro.神经生长因子在体外对解离的胚胎感觉和交感神经细胞存活及维持方面的重要作用。
Dev Biol. 1963 Mar;6:653-9. doi: 10.1016/0012-1606(63)90149-0.
3
A new class of tyrosine hydroxylase inhibitors and a simple assay of inhibition in vivo.一类新型酪氨酸羟化酶抑制剂及一种简单的体内抑制测定法。
Biochem Pharmacol. 1967 Jul 7;16(7):1313-21. doi: 10.1016/0006-2952(67)90162-1.
4
Second symposium on catecholamines. Modification of sympathetic function. Immunosympathectomy.第二届儿茶酚胺研讨会。交感神经功能的改变。免疫交感神经切除术。
Pharmacol Rev. 1966 Mar;18(1):619-28.
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Increase in tyrosine hydroxylase activity after reserpine administration.利血平给药后酪氨酸羟化酶活性增加。
J Pharmacol Exp Ther. 1969 Sep;169(1):74-9.
6
Selective induction by nerve growth factor of tyrosine hydroxylase and dopamine- -hydroxylase in the rat superior cervical ganglia.神经生长因子对大鼠颈上神经节中酪氨酸羟化酶和多巴胺-β-羟化酶的选择性诱导作用。
Proc Natl Acad Sci U S A. 1971 Jul;68(7):1598-602. doi: 10.1073/pnas.68.7.1598.
7
Pheochromocytoma.嗜铬细胞瘤
Cancer. 1972 Feb;29(2):327-31. doi: 10.1002/1097-0142(197202)29:2<327::aid-cncr2820290210>3.0.co;2-3.
8
Nerve growth factor.神经生长因子
Physiol Rev. 1968 Jul;48(3):534-69. doi: 10.1152/physrev.1968.48.3.534.
9
Primary cultures of dissociated sympathetic neurons. I. Establishment of long-term growth in culture and studies of differentiated properties.解离交感神经元的原代培养。I. 培养中长期生长的建立及分化特性研究。
J Cell Biol. 1973 Nov;59(2 Pt 1):329-45. doi: 10.1083/jcb.59.2.329.
10
A dissociated cell culture bioassay for nerve growth factor.一种用于神经生长因子的解离细胞培养生物测定法。
Neurobiology. 1974;4(5):286-92.

神经生长因子介导的克隆性嗜铬细胞瘤细胞系中酪氨酸羟化酶的诱导

Nerve growth factor-mediated induction of tyrosine hydroxylase in a clonal pheochromocytoma cell line.

作者信息

Goodman R, Herschman H R

出版信息

Proc Natl Acad Sci U S A. 1978 Sep;75(9):4587-90. doi: 10.1073/pnas.75.9.4587.

DOI:10.1073/pnas.75.9.4587
PMID:30087
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC336162/
Abstract

We have established a clonal cell line, PC-G2, from an experimentally induced rat pheochromocytoma. Administration of nerve growth factor to PC-G2 causes a 4- to 8-fold induction in the specific activity of tyrosine hydroxylase [tyrosine 3-monooxygenase; L-tyrosine,tetrahydropteridine:oxygen oxidoreductase(3-hydroxylating); EC 1.14.16.2]. The response is elicited in a dose-dependent fashion, at concentrations above 0.1 microgram/ml. Antiserum to nerve growth factor inhibited the induction of tyrosine hydroxylase. Dexamethasone enhances the nerve growth factor-mediated elevation of tyrosine hydroxylase. After 3--4 days of exposure to nerve growth factor the maximal induction of tyrosine hydroxylase is seen, although a significant increase can be observed after 24 hr. In contrast to the PC-12 cell line (derived from the same tumor), in which neurite outgrowth occurs in response to nerve growth factor, there is no morphological change or alteration in growth rate of PC-G2 cells after exposure to nerve growth factor.

摘要

我们从实验诱导的大鼠嗜铬细胞瘤中建立了一个克隆细胞系PC-G2。向PC-G2细胞系施用神经生长因子会导致酪氨酸羟化酶[酪氨酸3-单加氧酶；L-酪氨酸，四氢蝶呤：氧氧化还原酶(3-羟化)；EC 1.14.16.2]的比活性提高4至8倍。在浓度高于0.1微克/毫升时，以剂量依赖方式引发该反应。抗神经生长因子血清抑制酪氨酸羟化酶的诱导。地塞米松增强神经生长因子介导的酪氨酸羟化酶升高。在暴露于神经生长因子3至4天后，可观察到酪氨酸羟化酶的最大诱导，尽管在24小时后即可观察到显著增加。与PC-12细胞系（源自同一肿瘤）不同，PC-12细胞系在暴露于神经生长因子时会发生神经突生长，而PC-G2细胞在暴露于神经生长因子后没有形态变化或生长速率改变。