Ikeno T, Guroff G
Mol Cell Biochem. 1979 Dec 14;28(1-3):67-91. doi: 10.1007/BF00223360.
Although a great deal of descriptive information has been obtained about the actions of nerve growth factor on its target tissues, its structure, its receptors, and even its biosynthesis, there is no clear understanding, as yet, of the intracellular events mediating its transcriptional involvements. Work in this laboratory over the past five years has uncovered a number of nerve growth factor-initiated intracellular changes in sympathetic neurons and other nerve growth factor-sensitive systems, and has provided a framework into which they might fit. This article is written in an attempt to collect the data in a single communication and to suggest at least one mechanism by which the nerve growth factor may work.
尽管已经获得了大量关于神经生长因子对其靶组织的作用、其结构、其受体乃至其生物合成的描述性信息，但对于介导其转录参与的细胞内事件，目前仍尚无清晰的认识。在过去五年中，本实验室的研究揭示了交感神经元及其他对神经生长因子敏感的系统中，一些由神经生长因子引发的细胞内变化，并提供了一个它们可能适用的框架。撰写本文旨在将这些数据汇总于一篇文章中，并提出至少一种神经生长因子可能发挥作用的机制。
