FOXO3基因变异与长寿的关联研究。
An association study of FOXO3 variant and longevity.
作者信息
Silva-Sena Geralda Gillian, Camporez Daniela, Santos Lígia Ramos Dos, Silva Aline Sesana da, Sagrillo Pimassoni Lúcia Helena, Tieppo Alessandra, Pimentel Batitucci Maria do Carmo, Morelato Renato Lírio, Paula Flavia de
机构信息
Programa de Pós-Graduação em Biotecnologia, Renorbio, Universidade Federal do Espírito Santo, Vitória, ES, Brazil.
Departamento de Educação Integrada em Saúde, Centro de Ciências da Saúde, Universidade Federal do Espírito Santo, Vitória, ES, Brazil.
出版信息
Genet Mol Biol. 2018;41(2):386-396. doi: 10.1590/1678-4685-GMB-2017-0169. Epub 2018 Jun 11.
Human longevity is a polygenic and multifactorial trait. Pathways related to lifespan are complex and involve molecular, cellular, and environmental processes. In this analytical observational study, we evaluated the relationship between environment factors, oxidative stress status, DNA integrity level, and the association of FOXO3 (rs2802292), SOD2 (rs4880), APOE (rs429358 and rs7412), and SIRT1 (rs2273773) polymorphisms with longevity in oldest-old individuals from southeastern Brazil. We found an association between the FOXO3 GG genotype and gender. While lifestyle, anthropometric, and biochemical characteristics showed significant results, DNA damage and oxidative stress were not related to lifespan. We found that long-lived individuals with FOXO3 GT genotype had low levels of triglycerides. This study is the first to demonstrate that FOXO3 could be a candidate gene for longevity in the Brazilian population. These results are important in terms of provisions of health care for age-related diseases and lifespan, and provide insight for further research on epigenetic, gene regulation, and expression in oldest-old individuals.
人类长寿是一种多基因和多因素的性状。与寿命相关的途径很复杂，涉及分子、细胞和环境过程。在这项分析性观察研究中，我们评估了环境因素、氧化应激状态、DNA完整性水平，以及FOXO3（rs2802292）、SOD2（rs4880）、APOE（rs429358和rs7412）和SIRT1（rs2273773）基因多态性与巴西东南部高龄老人长寿之间的关联。我们发现FOXO3 GG基因型与性别之间存在关联。虽然生活方式、人体测量和生化特征显示出显著结果，但DNA损伤和氧化应激与寿命无关。我们发现携带FOXO3 GT基因型的长寿个体甘油三酯水平较低。本研究首次证明FOXO3可能是巴西人群中长寿的候选基因。这些结果对于为与年龄相关的疾病和寿命提供医疗保健具有重要意义，并为进一步研究高龄老人的表观遗传学、基因调控和表达提供了见解。
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