Tyrovolas Stefanos, Polychronopoulos Evangelos, Mariolis Anargiros, Piscopo Suzanne, Valacchi Giuseppe, Makri Kornilia, Zeimbekis Akis, Tyrovola Dimitra, Bountziouka Vassiliki, Gotsis Efthimios, Metallinos George, Tur Josep-Antoni, Matalas Antonia, Lionis Christos, Haro Josep Maria, Panagiotakos Demosthenes B
1 Parc Sanitari Sant Joan de Déu, Fundació Sant Joan de Déu, CIBERSAM, Universitat de Barcelona, Barcelona, Spain.
2 Department of Nutrition and Dietetics, School of Health Science and Education, Harokopio University, Athens, Greece.
Angiology. 2017 Feb;68(2):124-131. doi: 10.1177/0003319716642140. Epub 2016 Jul 11.
The aim of the present study was to evaluate the role of parental longevity and parental cardiovascular disease (CVD) history in CVD risk and successful aging of a random sample of older adults living in the Mediterranean basin and who participated in the MEDiterranean Islands (MEDIS) study. During 2005 to 2011, 2663 elders were voluntarily enrolled. A multidimensional successful aging index consisting of 10 components was used. Paternal and maternal longevity was defined as those older participants of whom both parents lived above the age of 90. The burden of CVD-related factors (CVD-RFs) was calculated as the total score of 4 major CVD-RFs (range 0-4). After adjustment, parental longevity was inversely associated with the burden of CVD-RFs ( P = .04). Moreover, parental longevity was positively associated with the older adults' successful aging score (β-coefficient [95% confidence interval]: .38 [0.06-0.71]). Parent's long living was revealed as an important factor for successful aging and for reduced CVD risk, suggesting that further research is needed in the genetic predisposition of longevity.
本研究的目的是评估父母长寿和父母心血管疾病（CVD）病史在地中海盆地居住的、参与地中海岛屿（MEDIS）研究的随机抽样老年人的CVD风险和成功老龄化中的作用。在2005年至2011年期间，2663名老年人自愿参与。使用了一个由10个成分组成的多维成功老龄化指数。父母的长寿被定义为父母双方均活到90岁以上的老年参与者。CVD相关因素（CVD-RFs）的负担被计算为4种主要CVD-RFs的总分（范围0至4）。经过调整后，父母长寿与CVD-RFs的负担呈负相关（P = 0.04）。此外，父母长寿与老年人的成功老龄化得分呈正相关（β系数[95%置信区间]：0.38[0.06 - 0.71]）。父母长寿被证明是成功老龄化和降低CVD风险的一个重要因素，这表明需要对长寿的遗传易感性进行进一步研究。
