Bánky Z, Halász B, Nagy G
Brain Res. 1986 Mar 26;369(1-2):119-24. doi: 10.1016/0006-8993(86)90519-6.
In order to study the role of the serotoninergic innervation of the hypothalamic suprachiasmatic nucleus (SCN) in the development of the circadian rhythm of corticosterone 5,7-dihydroxytryptamine (5,7-DHT) selectively destroying the serotoninergic structures was injected into the cell group of 16-day-old male rats prior to the appearance of the corticosterone rhythm. Rats treated with 5,7-DHT did not show circadian fluctuations in plasma corticosterone concentrations 3, 5 and 7 weeks after the injection of the neurotoxin. Their hypothalamo-pituitary-adrenal system responded to ether stress. Immunocytochemistry revealed that only a very few serotonin immunoreactive elements were visible in the SCN of the 5,7-DHT-treated rats. The results indicate that serotoninergic innervation of the SCN is essential for the development of the corticosterone rhythm.
为研究下丘脑视交叉上核（SCN）的5-羟色胺能神经支配在皮质酮昼夜节律形成中的作用，在皮质酮节律出现之前，向16日龄雄性大鼠的细胞群中注射选择性破坏5-羟色胺能结构的5,7-二羟基色胺（5,7-DHT）。注射神经毒素3、5和7周后，用5,7-DHT处理的大鼠血浆皮质酮浓度未出现昼夜波动。它们的下丘脑-垂体-肾上腺系统对乙醚应激有反应。免疫细胞化学显示，在5,7-DHT处理的大鼠的SCN中仅可见极少数5-羟色胺免疫反应性元素。结果表明，SCN的5-羟色胺能神经支配对皮质酮节律的形成至关重要。
