Feldman S, Conforti N, Melamed E
Brain Res Bull. 1987 Feb;18(2):165-8. doi: 10.1016/0361-9230(87)90186-9.
The purpose of this study was to further elucidate the role of serotonin (5-HT) in adrenocortical regulation. The effects of stimulating the frontal cortex and extrahypothalamic limbic structures, on plasma corticosterone (CS) responses, were studied in rats with vehicle or 5,7-dihydroxytryptamine (5,7-DHT) injection into the midbrain raphe nuclei. In another group of rats the neurotoxin was injected locally into the paraventricular nucleus (PVN) in view of its importance in adrenocortical regulation, and the effects of photic and dorsal hippocampal stimulation on plasma CS were studied. 5,7-DHT caused a significant depletion of hypothalamic 5-HT and blocked the rise in plasma CS following the stimulation of the above neural modalities. These studies suggest that the PVN 5-HT mediates the adrenocortical responses following afferent neural stimuli.
本研究的目的是进一步阐明血清素（5-羟色胺，5-HT）在肾上腺皮质调节中的作用。在向中脑缝际核注射赋形剂或5,7-二羟基色胺（5,7-DHT）的大鼠中，研究了刺激额叶皮质和下丘脑外边缘结构对血浆皮质酮（CS）反应的影响。鉴于室旁核（PVN）在肾上腺皮质调节中的重要性，在另一组大鼠中，将神经毒素局部注射到室旁核中，并研究了光刺激和海马背侧刺激对血浆CS的影响。5,7-DHT导致下丘脑5-HT显著耗竭，并阻断了上述神经刺激方式后血浆CS的升高。这些研究表明，室旁核5-HT介导了传入神经刺激后的肾上腺皮质反应。
