The State Key Laboratory of Functions & Applications of Medicinal Plants, Guizhou Medical University, Guiyang 550014, PR China.
The Key Laboratory of Chemistry for Natural Products of Guizhou Province & Chinese Academic of Sciences, Guiyang 550014, PR China.
Epigenomics. 2019 Jan;11(1):1635-1651. doi: 10.2217/epi-2018-0080. Epub 2018 Aug 9.
The potential functions and underlying mechanism of microfibrillar-associated proteins (MFAPs) are explored in human cancers.
MATERIALS & METHODS: Here, we examined the expression profiles, prognostic values, epigenetic and genetic alterations of MFAPs in human cancers from public omics repository.
Among MFAPs family, MFAP4 was frequently downregulated in the most human cancers and high mRNA expression of MFAP4 significantly correlated with better overall survival in breast cancer. DNA hypermethylation in the promoter of MFAP4 decreased its mRNA expression. MFAP4 strongly associated with pathway in impairment and alteration of the elastic fibers.
This integrated analysis provides new insights into MFAPs in human cancers and indicates that MFAP4 could be used as novel biomarker for developing therapies against human cancers.
探索微纤维相关蛋白（MFAPs）在人类癌症中的潜在功能和作用机制。
本文从公共组学数据库中检测了人类癌症中 MFAPs 的表达谱、预后价值、表观遗传和遗传改变。
在 MFAPs 家族中，MFAP4 在大多数人类癌症中经常下调，且 MFAP4 的高 mRNA 表达与乳腺癌患者的总生存期显著相关。MFAP4 启动子中的 DNA 超甲基化降低了其 mRNA 表达。MFAP4 与弹性纤维损伤和改变的途径密切相关。
这项综合分析为人类癌症中的 MFAPs 提供了新的见解，并表明 MFAP4 可作为开发针对人类癌症治疗方法的新型生物标志物。
