Jensen Louise K, Henriksen Nicole L, Jensen Henrik E
Department of Veterinary and Animal Science, University of Copenhagen, Copenhagen, Denmark.
Lab Anim. 2019 Apr;53(2):125-136. doi: 10.1177/0023677218789444. Epub 2018 Aug 8.
During the last 10 years the number of porcine models for human bacterial infectious diseases has increased. In the future, this tendency is expected to continue and, therefore, the aim of the present review is to describe guidelines for the development and reporting of these models. The guidelines are based on a review of 122 publications of porcine models for different bacterial infectious diseases in humans. The review demonstrates a substantial lack of information in most papers which hampers reproducibility and continuation of the work that was established in the models. The guidelines describe overall principles related to the inoculum, the animal, the infected animal and the post-mortem characterization that are of crucial importance when porcine models of infectious diseases are developed, validated and reported.
在过去10年中，用于人类细菌性传染病的猪模型数量有所增加。未来，预计这一趋势将持续，因此，本综述的目的是描述这些模型开发和报告的指南。这些指南基于对122篇关于人类不同细菌性传染病猪模型的出版物的综述。该综述表明，大多数论文存在大量信息缺失的情况，这妨碍了模型中已开展工作的可重复性和后续研究。这些指南描述了与接种物、动物、感染动物以及死后特征相关的总体原则，这些原则在开发、验证和报告传染病猪模型时至关重要。
