Ro J Y, Ayala A G, Ordonez N G, Cartwright J, Mackay B
Cancer. 1986 Jun 15;57(12):2397-407. doi: 10.1002/1097-0142(19860615)57:12<2397::aid-cncr2820571226>3.0.co;2-1.
Histochemical, immunohistochemical, electron microscopic, and x-ray microanalytic studies were performed on crystalloids within glandular lumina of adenocarcinomas of the prostate. In a review of light microscopic sections of 343 prostatic adenocarcinomas, unequivocal crystalloids were identified in 35 cases (10.2%). Immunohistochemical and ultrastructural studies revealed distinct differences between these crystalloids and the Bence Jones crystals of multiple myeloma: anti-kappa and anti-lamda immunostaining was negative, and the characteristic lattice-like architecture of Bence Jones crystals was not seen. Differences from corpora amylacea also were demonstrated. X-ray microanalysis did not elucidate the nature of the prostatic crystalloids, and their biochemical composition and mode of formation remain uncertain. Detection of the crystalloids in light microscopic sections nevertheless can aid in the diagnosis of prostatic adenocarcinoma, particularly when the tissue is distorted by crushing artifact, or if the tumor is so well-differentiated that it can be confused with atypical hyperplasia or inflammatory atypia. When intraluminal crystalloids are detected in prostatic glands that appear histologically benign or atypical, study of additional levels or a repeat biopsy should be undertaken.
对前列腺腺癌腺腔内的晶体进行了组织化学、免疫组织化学、电子显微镜和X射线微量分析研究。在对343例前列腺腺癌的光镜切片进行回顾时，在35例（10.2%）中发现了明确的晶体。免疫组织化学和超微结构研究显示，这些晶体与多发性骨髓瘤的本-周蛋白晶体存在明显差异：抗κ和抗λ免疫染色均为阴性，且未见到本-周蛋白晶体特有的晶格样结构。与前列腺凝固体的差异也得到了证实。X射线微量分析未能阐明前列腺晶体的性质，其生化组成和形成方式仍不确定。然而，在光镜切片中检测到这些晶体有助于前列腺腺癌的诊断，特别是当组织因挤压假象而变形时，或者当肿瘤分化良好以至于可能与非典型增生或炎症非典型性混淆时。当在组织学上看似良性或非典型的前列腺腺体内检测到腔内晶体时，应进行额外层面的研究或重复活检。
