Serretta Vincenzo, Abrate Alberto, Siracusano Simone, Gesolfo Cristina Scalici, Vella Marco, Di Maida Fabrizio, Cangemi Antonina, Cicero Giuseppe, Barresi Elisabetta, Sanfilippo Chiara
Department of Surgical, Oncological and Stomatological Sciences, University of Palermo, Palermo, Italy.
Department of Human Pathology, University of Palermo, Palermo, Italy.
Urol Ann. 2018 Jul-Sep;10(3):280-286. doi: 10.4103/UA.UA_188_17.
The correlation between aggressive prostate cancer and obesity mainly based on body mass index (BMI) and pathology after surgery remains controversial.
The aim of the study was to correlate BMI, visceral adiposity index (VAI), and the plasmatic levels of leptin, adiponectin, and matrix metalloproteinase-3 (MMP-3), and biomarkers of adipose tissue function, with the detection of Gleason patterns 4 and 5 at biopsy.
Consecutive patients with prostate cancer at 12-core transrectal biopsy were enrolled. BMI, waist circumference (WC), blood samples to evaluate the plasmatic levels of triglycerides (TG) and high-density lipoproteins (HDL), adiponectin, leptin, and MMP-3 were obtained immediately before biopsy. The VAI was calculated according to the formula: WC/(39.68 + [1.88 × BMI]) × TG/1.03 × 1.31/HDL.
One hundred and forty-nine patients were entered. The median PSA, BMI, and VAI were 10.0 ng/ml, 27.6 kg/m, and 4.6, respectively. Gleason patterns 4 or 5 were detected in 68 (45.6%) patients; in 15 (41.7%), 31 (44.9%), and 22 (50.0%) among normal weight, overweight, and obese patients, respectively ( = 0.55). The statistical analysis did not show any significant correlation between BMI, VAI, the plasmatic levels of leptin, adiponectin, MMP-3, and the detection of Gleason patterns 4 and 5 at biopsy. A statistically significant association emerged with older age ( = 0.017) and higher PSA values ( = 0.02).
We did not find any association between BMI, VAI, the plasmatic levels of adiponectin, leptin, and MMP-3 and the detection of Gleason patterns 4 and 5 at prostate biopsy.
侵袭性前列腺癌与肥胖之间的关联（主要基于体重指数（BMI）和术后病理）仍存在争议。
本研究旨在将BMI、内脏脂肪指数（VAI）、瘦素、脂联素和基质金属蛋白酶-3（MMP-3）的血浆水平以及脂肪组织功能生物标志物与活检时Gleason分级4级和5级的检测结果进行关联分析。
纳入经12针经直肠活检确诊为前列腺癌的连续患者。在活检前即刻测量BMI、腰围（WC），采集血样以评估甘油三酯（TG）和高密度脂蛋白（HDL）、脂联素、瘦素及MMP-3的血浆水平。VAI根据公式计算：WC/（39.68 + [1.88×BMI]）×TG/1.03×1.31/HDL。
共纳入149例患者。前列腺特异性抗原（PSA）、BMI和VAI的中位数分别为10.0 ng/ml、27.6 kg/m²和4.6。68例（45.6%）患者检测到Gleason分级4级或5级；正常体重、超重和肥胖患者中分别有15例（41.7%）、31例（44.9%）和22例（50.0%）（P = 0.55）。统计分析未显示BMI、VAI、瘦素、脂联素、MMP-3的血浆水平与活检时Gleason分级4级和5级的检测结果之间存在任何显著相关性。年龄较大（P = 0.017）和PSA值较高（P = 0.02）与Gleason分级4级和5级的检测结果存在统计学显著关联。
我们未发现BMI、VAI、脂联素、瘦素和MMP-3的血浆水平与前列腺活检时Gleason分级4级和5级的检测结果之间存在任何关联。
