肥胖、饮食和脂代谢在前列腺癌中的新作用。
The emerging role of obesity, diet and lipid metabolism in prostate cancer.
机构信息
Department of Urology, European Institute of Oncology (IEO), Milan, Italy.
Department of Translational Medical Sciences, University 'Federico II', Naples, Italy.
出版信息
Future Oncol. 2017 Feb;13(3):285-293. doi: 10.2217/fon-2016-0217. Epub 2016 Sep 14.
Abstract
Obesity is associated with an increased risk of a number of serious medical conditions, including cancer. As far as prostate cancer is concerned, obesity is associated with an increased risk of high-grade tumors, which is possibly related to lower androgen levels. Diet may also affect prostate cancer risk since countries with a higher dietary fat intake also present higher prostate cancer mortality rates. Interestingly, prostate cancer is associated with a number of metabolic alterations that may provide valuable diagnostic and therapeutic targets. This review explores the available clinical as well as biological evidence supporting the relationship between obesity, diet, alteration in metabolic pathways and prostate cancer.
摘要
肥胖与许多严重的健康问题相关，包括癌症。就前列腺癌而言，肥胖与高级别肿瘤的风险增加相关，这可能与雄激素水平降低有关。饮食也可能影响前列腺癌的风险，因为摄入较高脂肪的国家，前列腺癌死亡率也较高。有趣的是，前列腺癌与许多代谢改变相关，这些改变可能为诊断和治疗提供有价值的靶点。本综述探讨了肥胖、饮食、代谢途径改变与前列腺癌之间关系的现有临床和生物学证据。
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