银纳米颗粒的半胱氨酸诱导的兴奋效应。
Cysteine-induced hormesis effect of silver nanoparticles.
作者信息
Guo Zhi, Chen Guiqiu, Zeng Guangming, Huang Zhenzhen, Chen Anwei, Hu Liang, Wang Jiajia, Jiang Longbo
机构信息
College of Environmental Science and Engineering , Hunan University , Changsha 410082 , P.R. China . Email:
Key Laboratory of Environmental Biology and Pollution Control (Hunan University) , Ministry of Education , Changsha 410082 , P.R. China.
出版信息
Toxicol Res (Camb). 2016 Jul 26;5(5):1268-1272. doi: 10.1039/c6tx00222f. eCollection 2016 Sep 1.
The toxicity of silver nanoparticles (AgNPs) is widely exploited, but their hormesis effect has, so far, received little attention. This study reports the hormesis effect at low AgNPs concentrations of 0.34 mg L, with a 29.9% increase in bacterial viability compared with the control. Cysteine can induce a hormesis effect at a higher concentration. 12.5 mg L cysteine induced a hormesis effect in the AgNP concentration range of 1.7-5.1 mg L. Results suggest that this cysteine-induced hormesis effect is concentration-dependent; the concentration that make sulfuration rate (/) of 6.15 shows strong excitation to cells.
银纳米颗粒（AgNPs）的毒性被广泛研究，但迄今为止，它们的兴奋效应很少受到关注。本研究报告了在0.34毫克/升的低AgNPs浓度下的兴奋效应，与对照组相比，细菌活力增加了29.9%。半胱氨酸在较高浓度下可诱导兴奋效应。12.5毫克/升的半胱氨酸在1.7-5.1毫克/升的AgNP浓度范围内诱导了兴奋效应。结果表明，这种半胱氨酸诱导的兴奋效应是浓度依赖性的；使硫化率（/）为6.15的浓度对细胞表现出强烈的刺激作用。
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