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A novel human mAb (MERS-GD27) provides prophylactic and postexposure efficacy in MERS-CoV susceptible mice.一种新型人源单克隆抗体（MERS-GD27）在对中东呼吸综合征冠状病毒（MERS-CoV）易感的小鼠中具有预防和暴露后治疗效果。
Sci China Life Sci. 2018 Oct;61(10):1280-1282. doi: 10.1007/s11427-018-9343-8. Epub 2018 Aug 7.
2
Ultrapotent Human Neutralizing Antibody Repertoires Against Middle East Respiratory Syndrome Coronavirus From a Recovered Patient.针对中东呼吸综合征冠状病毒的超强人源中和抗体库源自一位康复患者。
J Infect Dis. 2018 Sep 8;218(8):1249-1260. doi: 10.1093/infdis/jiy311.
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Single-dose treatment with a humanized neutralizing antibody affords full protection of a human transgenic mouse model from lethal Middle East respiratory syndrome (MERS)-coronavirus infection.用人源化中和抗体进行单剂量治疗可使人类转基因小鼠模型完全免受致命的中东呼吸综合征（MERS）冠状病毒感染。
Antiviral Res. 2016 Aug;132:141-8. doi: 10.1016/j.antiviral.2016.06.003. Epub 2016 Jun 14.
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Characterization of a human monoclonal antibody generated from a B-cell specific for a prefusion-stabilized spike protein of Middle East respiratory syndrome coronavirus.一种针对中东呼吸综合征冠状病毒前融合稳定刺突蛋白的 B 细胞产生的人源单克隆抗体的鉴定。
PLoS One. 2020 May 8;15(5):e0232757. doi: 10.1371/journal.pone.0232757. eCollection 2020.
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A novel neutralizing monoclonal antibody targeting the N-terminal domain of the MERS-CoV spike protein.一种靶向中东呼吸综合征冠状病毒刺突蛋白N端结构域的新型中和单克隆抗体。
Emerg Microbes Infect. 2017 May 24;6(5):e37. doi: 10.1038/emi.2017.18.
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Prophylactic and postexposure efficacy of a potent human monoclonal antibody against MERS coronavirus.一种强效人源单克隆抗体对中东呼吸综合征冠状病毒的预防及暴露后疗效
Proc Natl Acad Sci U S A. 2015 Aug 18;112(33):10473-8. doi: 10.1073/pnas.1510199112. Epub 2015 Jul 27.
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Development of human neutralizing monoclonal antibodies for prevention and therapy of MERS-CoV infections.用于预防和治疗中东呼吸综合征冠状病毒（MERS-CoV）感染的人源中和单克隆抗体的研发。
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A Novel Nanobody Targeting Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Receptor-Binding Domain Has Potent Cross-Neutralizing Activity and Protective Efficacy against MERS-CoV.一种新型针对中东呼吸综合征冠状病毒（MERS-CoV）受体结合域的纳米抗体具有强大的交叉中和活性和针对 MERS-CoV 的保护效力。
J Virol. 2018 Aug 29;92(18). doi: 10.1128/JVI.00837-18. Print 2018 Sep 15.
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Passive Transfer of A Germline-like Neutralizing Human Monoclonal Antibody Protects Transgenic Mice Against Lethal Middle East Respiratory Syndrome Coronavirus Infection.被动转移一种类生殖系中和的人源单克隆抗体可保护转基因小鼠免受致死性中东呼吸综合征冠状病毒感染。
Sci Rep. 2016 Aug 19;6:31629. doi: 10.1038/srep31629.
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Towards a solution to MERS: protective human monoclonal antibodies targeting different domains and functions of the MERS-coronavirus spike glycoprotein.迈向 MERS 解决方案：针对 MERS 冠状病毒刺突糖蛋白不同结构域和功能的保护性人源单克隆抗体。
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Harnessing immunotherapeutic molecules and diagnostic biomarkers as human-derived adjuvants for MERS-CoV vaccine development.利用免疫治疗分子和诊断生物标志物作为人源佐剂用于中东呼吸综合征冠状病毒疫苗开发。
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A highly susceptible hACE2-transgenic mouse model for SARS-CoV-2 research.一种用于SARS-CoV-2研究的高度易感的hACE2转基因小鼠模型。
Front Microbiol. 2024 Feb 7;15:1348405. doi: 10.3389/fmicb.2024.1348405. eCollection 2024.
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The structure of a novel antibody against the spike protein inhibits Middle East respiratory syndrome coronavirus infections.一种新型针对刺突蛋白的抗体结构可抑制中东呼吸综合征冠状病毒感染。
Sci Rep. 2022 Jan 24;12(1):1260. doi: 10.1038/s41598-022-05318-4.
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Neutralizing monoclonal antibodies against highly pathogenic coronaviruses.针对高致病性冠状病毒的中和单克隆抗体。
Curr Opin Virol. 2022 Apr;53:101199. doi: 10.1016/j.coviro.2021.12.015. Epub 2021 Dec 30.
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Elevated plasma levels of selective cytokines in COVID-19 patients reflect viral load and lung injury.新冠病毒肺炎患者血浆中某些细胞因子水平升高反映了病毒载量和肺损伤。
Natl Sci Rev. 2020 Jun;7(6):1003-1011. doi: 10.1093/nsr/nwaa037. Epub 2020 Mar 9.
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Enhancing oxygenation of patients with coronavirus disease 2019: Effects on immunity and other health-related conditions.提高2019冠状病毒病患者的氧合：对免疫及其他健康相关状况的影响。
World J Clin Cases. 2021 Jul 6;9(19):4939-4958. doi: 10.12998/wjcc.v9.i19.4939.
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Molecular evidence suggesting the persistence of residual SARS-CoV-2 and immune responses in the placentas of pregnant patients recovered from COVID-19.分子证据表明，从 COVID-19 中康复的孕妇胎盘内仍存在 SARS-CoV-2 和免疫反应。
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Potent germline-like monoclonal antibodies: rapid identification of promising candidates for antibody-based antiviral therapy.强效类生殖系单克隆抗体：快速鉴定基于抗体的抗病毒疗法的有前景候选物。
Antib Ther. 2021 May 17;4(2):89-98. doi: 10.1093/abt/tbab008. eCollection 2021 Apr.
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Clinical characteristics of coronavirus disease 2019 (COVID-19) in patients out of Wuhan from China: a case control study.中国武汉以外地区 2019 年冠状病毒病（COVID-19）患者的临床特征：一项病例对照研究。
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Model Prediction for In-Hospital Mortality in Patients with COVID-19: A Case-Control Study in Isfahan, Iran.COVID-19患者院内死亡率的模型预测：伊朗伊斯法罕的一项病例对照研究
Am J Trop Med Hyg. 2021 Feb 16;104(4):1476-1483. doi: 10.4269/ajtmh.20-1039.

本文引用的文献

1
Pathogen genomic surveillance elucidates the origins, transmission and evolution of emerging viral agents in China.病原体基因组监测阐明了在中国出现的新病毒因子的起源、传播和进化。
Sci China Life Sci. 2017 Dec;60(12):1317-1330. doi: 10.1007/s11427-017-9211-0. Epub 2017 Nov 28.
2
Passive Transfer of A Germline-like Neutralizing Human Monoclonal Antibody Protects Transgenic Mice Against Lethal Middle East Respiratory Syndrome Coronavirus Infection.被动转移一种类生殖系中和的人源单克隆抗体可保护转基因小鼠免受致死性中东呼吸综合征冠状病毒感染。
Sci Rep. 2016 Aug 19;6:31629. doi: 10.1038/srep31629.
3
Single-dose treatment with a humanized neutralizing antibody affords full protection of a human transgenic mouse model from lethal Middle East respiratory syndrome (MERS)-coronavirus infection.用人源化中和抗体进行单剂量治疗可使人类转基因小鼠模型完全免受致命的中东呼吸综合征（MERS）冠状病毒感染。
Antiviral Res. 2016 Aug;132:141-8. doi: 10.1016/j.antiviral.2016.06.003. Epub 2016 Jun 14.
4
Exceptionally potent neutralization of Middle East respiratory syndrome coronavirus by human monoclonal antibodies.人源单克隆抗体对中东呼吸综合征冠状病毒的超强中和作用。
J Virol. 2014 Jul;88(14):7796-805. doi: 10.1128/JVI.00912-14. Epub 2014 Apr 30.
5
A safe and convenient pseudovirus-based inhibition assay to detect neutralizing antibodies and screen for viral entry inhibitors against the novel human coronavirus MERS-CoV.一种安全便捷的基于假病毒的抑制试验，用于检测中和抗体并筛选针对新型人冠状病毒 MERS-CoV 的病毒进入抑制剂。
Virol J. 2013 Aug 26;10:266. doi: 10.1186/1743-422X-10-266.
6
Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia.从沙特阿拉伯一名患有肺炎的男子中分离出一种新型冠状病毒。
N Engl J Med. 2012 Nov 8;367(19):1814-20. doi: 10.1056/NEJMoa1211721. Epub 2012 Oct 17.
7
Rapid generation of fully human monoclonal antibodies specific to a vaccinating antigen.快速生成针对疫苗接种抗原的完全人源单克隆抗体。
Nat Protoc. 2009;4(3):372-84. doi: 10.1038/nprot.2009.3.

A novel human mAb (MERS-GD27) provides prophylactic and postexposure efficacy in MERS-CoV susceptible mice.

作者信息

Niu Peihua, Zhao Guangyu, Deng Yao, Sun Shihui, Wang Wenling, Zhou Yusen, Tan Wenjie

机构信息

National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, 102206, China.

State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, 100850, China.

出版信息

Sci China Life Sci. 2018 Oct;61(10):1280-1282. doi: 10.1007/s11427-018-9343-8. Epub 2018 Aug 7.

DOI:10.1007/s11427-018-9343-8
PMID:30091015
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7089443/
Abstract
摘要