一般人群中与呼吸努力相关的觉醒的发生率及其临床意义。

Prevalence and Clinical Significance of Respiratory Effort-Related Arousals in the General Population.

机构信息

Center for Investigation and Research in Sleep, Lausanne University Hospital, Lausanne, Switzerland.

Department of Psychiatry, Lausanne University Hospital, Lausanne, Switzerland.

出版信息

J Clin Sleep Med. 2018 Aug 15;14(8):1339-1345. doi: 10.5664/jcsm.7268.

DOI:10.5664/jcsm.7268

PMID:30092888

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6086952/

Abstract

STUDY OBJECTIVES

To determine the prevalence and clinical associations of respiratory effort-related arousals (RERA) in a general population sample.

METHODS

A total of 2,162 participants (51.2% women, 58.5 ± 11.0 years old, body mass index [BMI] 25.6 ± 4.2 kg/m) of a general population-based cohort (HypnoLaus, Switzerland) underwent full polysomnography at home. Each subject with a RERA index ≥ 5 events/h was compared with an age-, sex- and apnea-hypopnea index (AHI)-matched control without RERA.

RESULTS

A RERA index ≥ 5 events/h was present in 84 participants (3.8%; 95% confidence interval: 3.2-4.8%). In 17 participants (0.8%; 95% confidence interval: 0.5-1.3%), RERAs were the predominant sleep breathing disorder and only one of them complained of excessive daytime sleepiness. Compared to matched controls, subjects with a RERA index ≥ 5 events/h were similar in terms of BMI (26.5 ± 3.5 versus 26.3 ± 4.8 kg/m, = .73), neck circumference (38.5 ± 3.3 versus 37.6 ± 3.7 cm, = .10) and Epworth Sleepiness Scale score (6.7 ± 3.7 versus 6.0 ± 3.7, = .22). Also, no differences were found for hypertension (21.4% versus 27.4%, = .47), diabetes (7.1% versus 7.1%, = 1.00), or metabolic syndrome (31.0% versus 23.8%, = .39).

CONCLUSIONS

In a middle-aged population-based cohort, the prevalence of a RERA index ≥ 5 events/h was low (3.8%) and was not associated with negative clinical outcomes when using the currently recommended scoring criteria of the American Academy of Sleep Medicine.

摘要

研究目的

在一般人群样本中确定与呼吸努力相关觉醒（RERA）相关的患病率和临床关联。

方法

共有 2162 名（51.2%女性，58.5±11.0 岁，体重指数[BMI]25.6±4.2kg/m）来自一般人群为基础的队列（瑞士 HypnoLaus）的参与者在家中接受了完整的多导睡眠图。每个 RERA 指数≥5 事件/小时的受试者与没有 RERA 的年龄、性别和呼吸暂停低通气指数（AHI）匹配的对照进行比较。

结果

84 名参与者（3.8%；95%置信区间：3.2-4.8%）存在 RERA 指数≥5 事件/小时。在 17 名参与者（0.8%；95%置信区间：0.5-1.3%）中，RERAs 是主要的睡眠呼吸障碍，其中只有一名抱怨白天过度嗜睡。与匹配对照相比，RERA 指数≥5 事件/小时的受试者在 BMI（26.5±3.5 与 26.3±4.8kg/m，=.73）、颈围（38.5±3.3 与 37.6±3.7cm，=.10）和 Epworth 睡眠量表评分（6.7±3.7 与 6.0±3.7，=.22）方面相似。此外，高血压（21.4%与 27.4%，=.47）、糖尿病（7.1%与 7.1%，=1.00）或代谢综合征（31.0%与 23.8%，=.39）方面也没有差异。