乳腺癌干细胞与性激素
Breast Cancer Stem Cells and Sex Steroid Hormones.
机构信息
Programa de Doctorado en Ciencias Biomédicas, Universidad Nacional Autónoma de México, CDMX, México.
Departamento de Investigacion Basica, Instituto Nacional de Cancerologia, Av. San Fernando No. 22, Col. Seccion XVI, Tlalpan 14080, CDMX, Mexico.
出版信息
Curr Stem Cell Res Ther. 2019;14(5):398-404. doi: 10.2174/1574888X13666180810121415.
Breast cancer stem cells (BCSCs) are a small population of tumor-initiating cells that express stem cell-associated markers. In recent years, their properties and mechanisms of regulation have become the focus of intense research due to their intrinsic resistance to conventional cancer therapies. This review describes breast cancer stem cell origin, signaling pathways involved in self-renewal, such as Wnt, Notch and Hedgehog, biomarkers linked to stemness, and the role of sex steroid hormones in BCSC regulation.
乳腺癌干细胞（BCSCs）是一小群表达干细胞相关标记物的肿瘤起始细胞。近年来，由于其对传统癌症治疗的固有耐药性，它们的特性和调控机制成为了研究的热点。本文综述了乳腺癌干细胞的起源、自我更新相关的信号通路（如 Wnt、Notch 和 Hedgehog）、与干细胞特性相关的标志物，以及性激素在 BCSC 调控中的作用。
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