Department of Molecular Oncology, BC Cancer Research Centre, Vancouver, British Columbia, Canada; and.
Department of Radiology, University of British Columbia, Vancouver, British Columbia, Canada.
J Nucl Med. 2018 Dec;59(12):1865-1868. doi: 10.2967/jnumed.118.215350. Epub 2018 Aug 10.
We evaluated the ability of monosodium glutamate (MSG) to reduce salivary and kidney uptake of a prostate-specific membrane antigen (PSMA) radioligand without affecting tumor uptake. LNCaP tumor-bearing mice were intraperitoneally injected with MSG (657, 329, or 164 mg/kg) or phosphate-buffered saline (PBS). Fifteen minutes later, the mice were intravenously administered Ga-PSMA-11. PET/CT imaging and biodistribution studies were performed 1 h after administration. Tumor uptake (percentage injected dose per gram [%ID]) was not statistically different between groups, at 8.42 ± 1.40 %ID in the 657 mg/kg group, 7.19 ± 0.86 %ID in the 329 mg/kg group, 8.20 ± 2.44 %ID in the 164 mg/kg group, and 8.67 ± 1.97 %ID in the PBS group. Kidney uptake was significantly lower in the 657 mg/kg group (85.8 ± 24.2 %ID) than in the 329 mg/kg (159 ± 26.2 %ID), 164 mg/kg (211 ± 27.4 %ID), and PBS groups (182 ± 33.5 %ID) ( < 0.001). Salivary gland uptake was lower in the 657 mg/kg (3.72 ± 2.12 %ID) and 329 mg/kg (5.74 ± 0.62 %ID) groups than in the PBS group (10.04 ± 2.52 %ID) ( < 0.01). MSG decreased salivary and kidney uptake of Ga-PSMA-11 in a dose-dependent manner, whereas tumor uptake was unaffected.
我们评估了谷氨酸单钠（MSG）降低前列腺特异性膜抗原（PSMA）放射性配体唾液和肾脏摄取而不影响肿瘤摄取的能力。LNCaP 肿瘤荷瘤小鼠经腹腔注射 MSG（657、329 或 164mg/kg）或磷酸盐缓冲盐水（PBS）。15 分钟后，小鼠静脉注射 Ga-PSMA-11。给药后 1 小时进行 PET/CT 成像和生物分布研究。肿瘤摄取（每克注射剂量的百分比[ID]）在各组之间无统计学差异，657mg/kg 组为 8.42±1.40%ID，329mg/kg 组为 7.19±0.86%ID，164mg/kg 组为 8.20±2.44%ID，PBS 组为 8.67±1.97%ID。657mg/kg 组肾脏摄取（85.8±24.2%ID）明显低于 329mg/kg（159±26.2%ID）、164mg/kg（211±27.4%ID）和 PBS 组（182±33.5%ID）（<0.001）。657mg/kg（3.72±2.12%ID）和 329mg/kg（5.74±0.62%ID）组唾液腺摄取均低于 PBS 组（10.04±2.52%ID）（<0.01）。MSG 以剂量依赖的方式降低 Ga-PSMA-11 的唾液和肾脏摄取，而肿瘤摄取不受影响。
