Newton Andrew D, Predina Jarrod D, Nie Shuming, Low Philip S, Singhal Sunil
Department of Surgery, University of Pennsylvania, Perelman School of Medicine, Philadelphia, Pennsylvania.
Department of Bioengineering, University of Illinois at Urbana-Champaign, Urbana, Illinois.
J Surg Oncol. 2018 Aug;118(2):344-355. doi: 10.1002/jso.25149. Epub 2018 Aug 11.
Intraoperative fluorescence imaging (IFI) can improve real-time identification of cancer cells during an operation. Phase I clinical trials in thoracic surgery have demonstrated that IFI with second window indocyanine green (TumorGlow ) can identify subcentimeter pulmonary nodules, anterior mediastinal masses, and mesothelioma, while the use of a folate receptor-targeted near-infrared agent, OTL38, can improve the specificity for diagnosing tumors with folate receptor expression. Here, we review the existing preclinical and clinical data on IFI in thoracic surgery.
术中荧光成像（IFI）可在手术过程中提高癌细胞的实时识别能力。胸外科的I期临床试验表明，使用第二窗口吲哚菁绿（TumorGlow）进行的IFI能够识别亚厘米级的肺结节、前纵隔肿块和间皮瘤，而使用叶酸受体靶向近红外剂OTL38可提高对有叶酸受体表达肿瘤的诊断特异性。在此，我们综述了胸外科术中荧光成像的现有临床前和临床数据。
