Thoracic Medicine Department 1, The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University/Hunan Cancer Hospital, Changsha 410013, China.
School of Life and Health Sciences, Hunan University of Science and Technology, Xiangtan 411201, China.
Biosensors (Basel). 2024 Oct 14;14(10):501. doi: 10.3390/bios14100501.
Lung cancer is a major threat to human health and a leading cause of death. Accurate localization of tumors in vivo is crucial for subsequent treatment. In recent years, fluorescent imaging technology has become a focal point in tumor diagnosis and treatment due to its high sensitivity, strong selectivity, non-invasiveness, and multifunctionality. Molecular probes-based fluorescent imaging not only enables real-time in vivo imaging through fluorescence signals but also integrates therapeutic functions, drug screening, and efficacy monitoring to facilitate comprehensive diagnosis and treatment. Among them, near-infrared (NIR) fluorescence imaging is particularly prominent due to its improved in vivo imaging effect. This trend toward multifunctionality is a significant aspect of the future advancement of fluorescent imaging technology. In the past years, great progress has been made in the field of NIR fluorescence imaging for lung cancer management, as well as the emergence of new problems and challenges. This paper generally summarizes the application of NIR fluorescence imaging technology in these areas in the past five years, including the design, detection principles, and clinical applications, with the aim of advancing more efficient NIR fluorescence imaging technologies to enhance the accuracy of tumor diagnosis and treatment.
肺癌是严重威胁人类健康的主要疾病之一，也是导致死亡的主要原因之一。肿瘤在体内的准确定位对于后续的治疗至关重要。近年来，荧光成像技术由于其高灵敏度、强选择性、非侵入性和多功能性而成为肿瘤诊断和治疗的焦点。基于分子探针的荧光成像是通过荧光信号实现实时活体成像，并集成治疗功能、药物筛选和疗效监测，从而促进全面的诊断和治疗。其中，近红外（NIR）荧光成像由于其改善的体内成像效果而尤为突出。这种多功能化趋势是荧光成像技术未来发展的一个重要方面。在过去的几年中，NIR 荧光成像在肺癌管理领域取得了很大进展，同时也出现了新的问题和挑战。本文综述了过去五年中 NIR 荧光成像技术在这些领域的应用，包括设计、检测原理和临床应用，旨在推进更高效的 NIR 荧光成像技术，提高肿瘤诊断和治疗的准确性。
