Rosenthal R C, Koritz G D, Davis L E
J Vet Pharmacol Ther. 1986 Mar;9(1):81-7. doi: 10.1111/j.1365-2885.1986.tb00015.x.
The pharmacokinetics of lithium were determined in eight adult dogs. The data were fitted to a two-compartment model. Single intravenous doses of lithium chloride, and single oral doses of lithium carbonate were used. The mean plasma lithium half-life (t1/2) following the single intravenous dose was 21.6 h, and the mean apparent specific volume of distribution of the central compartment (V'c) was 0.189 l/kg. Mean bioavailability was 78.8% following oral administration.
在八只成年犬中测定了锂的药代动力学。数据拟合为二室模型。使用了单次静脉注射氯化锂和单次口服碳酸锂。单次静脉注射后血浆锂的平均半衰期（t1/2）为21.6小时，中央室的平均表观分布比容（V'c）为0.189升/千克。口服给药后的平均生物利用度为78.8%。
